Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii

doi:10.1055/s-0032-1328399

NWIPB OpenIR

	Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii
	Cao, Tuan-Wu 1,3; Geng, Chang-An 1; Ma, Yun-Bao 1; He, Kang 1; Wang, Hong-Ling 1,3; Zhou, Ning-Jia 1,3; Zhang, Xue-Mei 1; Tao, Yan-Duo 2; Chen, Ji-Jun 1; Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China.
	2013-05-01
发表期刊	PLANTA MEDICA
ISSN	0032-0943
卷号	79 期号:8 页码:697-700
文章类型	Article
摘要	Two new xanthones, 8-O-beta-D-glucopyranosyl-1-hydroxy-2,3,5-trimethoxyxanthone (1) and 8-O-[beta-D-xylopyranosyl-(1 -> 6)-beta-D-glucopyranosyl]-1-hydroxy-2,3,5-trimethoxyxanthone (2), along with eighteen known xanthones (3-20) were isolated from Swertia mussotii. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [alpha](D)). All compounds were evaluated for their anti-hepatitis B virus activities on HepG 2.2.15 cells line in vitro, and compounds 3-10 exhibited significant activity inhibiting hepatitis B virus DNA replication with IC50 values from 0.01 mM to 0.13 mM. Compounds 3-5 showed remarkable activity with IC50 values of 0.77, >0.98, and 0.21 mM for HBsAg, and <0.62, 0.35, and 0.04 mM for HBeAg, respectively. Meanwhile, the effects of different substitutions on the anti-hepatitis B virus activity of xanthones from S. mussotii were discussed.; Two new xanthones, 8-O-beta-D-glucopyranosyl-1-hydroxy-2,3,5-trimethoxyxanthone (1) and 8-O-[beta-D-xylopyranosyl-(1 -> 6)-beta-D-glucopyranosyl]-1-hydroxy-2,3,5-trimethoxyxanthone (2), along with eighteen known xanthones (3-20) were isolated from Swertia mussotii. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [alpha](D)). All compounds were evaluated for their anti-hepatitis B virus activities on HepG 2.2.15 cells line in vitro, and compounds 3-10 exhibited significant activity inhibiting hepatitis B virus DNA replication with IC50 values from 0.01 mM to 0.13 mM. Compounds 3-5 showed remarkable activity with IC50 values of 0.77, >0.98, and 0.21 mM for HBsAg, and <0.62, 0.35, and 0.04 mM for HBeAg, respectively. Meanwhile, the effects of different substitutions on the anti-hepatitis B virus activity of xanthones from S. mussotii were discussed.
关键词	Swertia Mussotii Gentianaceae Xanthones Anti-hbv Activity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1055/s-0032-1328399
关键词[WOS]	GLYCOSIDES
收录类别	SCI
语种	英语
项目资助者	National Science Foundation of China for Distinguished Young Scholars(81025023) ; International Foundation for Science(F/5202-1) ; National Natural Science Foundation of China ; Yunnan Province(U0832603) ; West Light Foundation of the Chinese Academy of Sciences
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000319466800015
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/3945
专题	中国科学院西北高原生物研究所
通讯作者	Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China.
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Res Ctr Biol Resources Qinghai Tibet Plateau, Xining, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Cao, Tuan-Wu,Geng, Chang-An,Ma, Yun-Bao,et al. Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii[J]. PLANTA MEDICA,2013,79(8):697-700.
APA	Cao, Tuan-Wu.,Geng, Chang-An.,Ma, Yun-Bao.,He, Kang.,Wang, Hong-Ling.,...&Chen, JJ .(2013).Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii.PLANTA MEDICA,79(8),697-700.
MLA	Cao, Tuan-Wu,et al."Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii".PLANTA MEDICA 79.8(2013):697-700.