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Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles
Zhang, Yaqin1; Liu, Bin2,3; Wu, Heming4; Li, Bin4; Xu, Junyong4; Duan, Lei2; Jiang, Caiyun5; Zhao, Xiaohui6; Yuan, Yi4; Zhang, Gen3,7; Zeng, Xin3,8
2014-12-01
发表期刊JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
ISSN1550-7033
卷号10期号:12页码:3638-3646
文章类型Article
摘要Verbascoside (VB), a major bioactive constituent of the Tsoong herb, has attracted a great deal of attention due to its pharmacological properties. In this study, we demonstrated the inhibitory effect of VB-loaded gold nanoparticles (VB-Au) on the growth of K562 cells both in vitro and in vivo. We found that, in contrast with the same concentration of gold nanoparticles (Au) or VB, VB-Au significantly decreased the viability of K562 cells and promoted the apoptosis of tumor cells. A tumor implantation mouse model further showed that the intravenous injection of VB-Au effectively inhibited the growth and induced the apoptosis of tumor cells. In conclusion, our results collectively demonstrate that VB-Au nanoparticles provide an effective strategy to control tumor cell growth.; Verbascoside (VB), a major bioactive constituent of the Tsoong herb, has attracted a great deal of attention due to its pharmacological properties. In this study, we demonstrated the inhibitory effect of VB-loaded gold nanoparticles (VB-Au) on the growth of K562 cells both in vitro and in vivo. We found that, in contrast with the same concentration of gold nanoparticles (Au) or VB, VB-Au significantly decreased the viability of K562 cells and promoted the apoptosis of tumor cells. A tumor implantation mouse model further showed that the intravenous injection of VB-Au effectively inhibited the growth and induced the apoptosis of tumor cells. In conclusion, our results collectively demonstrate that VB-Au nanoparticles provide an effective strategy to control tumor cell growth.
关键词Anti-cancer Nanoparticle Vb-au Drug-resistant K562 Cells
WOS标题词Science & Technology ; Technology
关键词[WOS]PLANT-CELL CULTURES ; FE-AT-AU ; BIOMEDICAL APPLICATIONS ; MAGNETIC NANOPARTICLES ; ELECTROCHEMICAL BIOSENSOR ; DRUG-DELIVERY ; L-GLUTAMATE ; ARRAY ; FABRICATION ; LEUKEMIA
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS类目Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS记录号WOS:000342793600013
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/4173
专题中国科学院西北高原生物研究所
作者单位1.Nanjing Med Univ, Sch Basic Med Sci, Dept Biochem Mol Biol, Nanjing 210029, Jiangsu, Peoples R China
2.Nanjing Med Univ, Sch Basic Med Sci, Dept Biomed Engn, Nanjing 210029, Jiangsu, Peoples R China
3.Southeast Univ, Dept Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China
4.Nanjing Med Univ, Inst Stomatol, Nanjing 210029, Jiangsu, Peoples R China
5.Jiangsu Inst Commerce, Dept Engn & Technol, Nanjing 211168, Jiangsu, Peoples R China
6.Chinese Acad Sci, Northwest Plateau Inst Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China
7.Nanjing Med Univ, Sch Basic Med Sci, Dept Cell Biol, Nanjing 210029, Jiangsu, Peoples R China
8.Nanjing Matern & Child Hlth Care Hosp, Maternal & Child Hlth Inst, Nanjing 210029, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yaqin,Liu, Bin,Wu, Heming,et al. Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2014,10(12):3638-3646.
APA Zhang, Yaqin.,Liu, Bin.,Wu, Heming.,Li, Bin.,Xu, Junyong.,...&Zeng, Xin.(2014).Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,10(12),3638-3646.
MLA Zhang, Yaqin,et al."Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 10.12(2014):3638-3646.
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