Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles | |
Zhang, Yaqin1; Liu, Bin2,3; Wu, Heming4; Li, Bin4; Xu, Junyong4; Duan, Lei2; Jiang, Caiyun5; Zhao, Xiaohui6; Yuan, Yi4; Zhang, Gen3,7; Zeng, Xin3,8 | |
2014-12-01 | |
发表期刊 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY |
ISSN | 1550-7033 |
卷号 | 10期号:12页码:3638-3646 |
文章类型 | Article |
摘要 | Verbascoside (VB), a major bioactive constituent of the Tsoong herb, has attracted a great deal of attention due to its pharmacological properties. In this study, we demonstrated the inhibitory effect of VB-loaded gold nanoparticles (VB-Au) on the growth of K562 cells both in vitro and in vivo. We found that, in contrast with the same concentration of gold nanoparticles (Au) or VB, VB-Au significantly decreased the viability of K562 cells and promoted the apoptosis of tumor cells. A tumor implantation mouse model further showed that the intravenous injection of VB-Au effectively inhibited the growth and induced the apoptosis of tumor cells. In conclusion, our results collectively demonstrate that VB-Au nanoparticles provide an effective strategy to control tumor cell growth.; Verbascoside (VB), a major bioactive constituent of the Tsoong herb, has attracted a great deal of attention due to its pharmacological properties. In this study, we demonstrated the inhibitory effect of VB-loaded gold nanoparticles (VB-Au) on the growth of K562 cells both in vitro and in vivo. We found that, in contrast with the same concentration of gold nanoparticles (Au) or VB, VB-Au significantly decreased the viability of K562 cells and promoted the apoptosis of tumor cells. A tumor implantation mouse model further showed that the intravenous injection of VB-Au effectively inhibited the growth and induced the apoptosis of tumor cells. In conclusion, our results collectively demonstrate that VB-Au nanoparticles provide an effective strategy to control tumor cell growth. |
关键词 | Anti-cancer Nanoparticle Vb-au Drug-resistant K562 Cells |
WOS标题词 | Science & Technology ; Technology |
关键词[WOS] | PLANT-CELL CULTURES ; FE-AT-AU ; BIOMEDICAL APPLICATIONS ; MAGNETIC NANOPARTICLES ; ELECTROCHEMICAL BIOSENSOR ; DRUG-DELIVERY ; L-GLUTAMATE ; ARRAY ; FABRICATION ; LEUKEMIA |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Biomaterials |
WOS记录号 | WOS:000342793600013 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/4173 |
专题 | 中国科学院西北高原生物研究所 |
作者单位 | 1.Nanjing Med Univ, Sch Basic Med Sci, Dept Biochem Mol Biol, Nanjing 210029, Jiangsu, Peoples R China 2.Nanjing Med Univ, Sch Basic Med Sci, Dept Biomed Engn, Nanjing 210029, Jiangsu, Peoples R China 3.Southeast Univ, Dept Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China 4.Nanjing Med Univ, Inst Stomatol, Nanjing 210029, Jiangsu, Peoples R China 5.Jiangsu Inst Commerce, Dept Engn & Technol, Nanjing 211168, Jiangsu, Peoples R China 6.Chinese Acad Sci, Northwest Plateau Inst Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China 7.Nanjing Med Univ, Sch Basic Med Sci, Dept Cell Biol, Nanjing 210029, Jiangsu, Peoples R China 8.Nanjing Matern & Child Hlth Care Hosp, Maternal & Child Hlth Inst, Nanjing 210029, Jiangsu, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Yaqin,Liu, Bin,Wu, Heming,et al. Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2014,10(12):3638-3646. |
APA | Zhang, Yaqin.,Liu, Bin.,Wu, Heming.,Li, Bin.,Xu, Junyong.,...&Zeng, Xin.(2014).Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,10(12),3638-3646. |
MLA | Zhang, Yaqin,et al."Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 10.12(2014):3638-3646. |
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