Knowledge Management System of Northwest Institute of Plateau Biology, CAS
| Two new sesquiterpenes from Artemisia sieversiana | |
| Liu, Shi-Jun1,3; Liao, Zhi-Xin1,3; Liu, Chao1; Ji, Lan-Ju2; Sun, Hong-Fa2 | |
| 2014-09-01 | |
| 发表期刊 | FITOTERAPIA
 |
| ISSN | 0367-326X |
| 卷号 | 97页码:43-49 |
| 文章类型 | Article |
| 摘要 | Two new sesquiterpenes, together with 32 known compounds(3-34), were isolated from Artemisia sieversiana Ehrhart ex willd. and the compounds 3-21 were isolated from this plant for the first time. The new compounds were elucidated as 2a,9a-dihydroxymuurol-3(4)-en-12-oic acid (1) and 13 alpha-methyl-(5 alpha H,6 alpha H,7 alpha H,8 alpha H)-austricin 8-O-beta-D-glucopyranoside (2), respectively. The structural identification of these compounds was mainly achieved by spectroscopic methods including 1D and 2D NMR techniques, and the structure of compound 1 was confirmed by a single crystal X-ray diffraction experiment. Compounds 1-2 were evaluated for cytotoxic activity in vitro against MCF-7, NCI-H460 and Hep-G2 cell lines, respectively. (c) 2014 Elsevier B.V. All rights reserved.; Two new sesquiterpenes, together with 32 known compounds(3-34), were isolated from Artemisia sieversiana Ehrhart ex willd. and the compounds 3-21 were isolated from this plant for the first time. The new compounds were elucidated as 2a,9a-dihydroxymuurol-3(4)-en-12-oic acid (1) and 13 alpha-methyl-(5 alpha H,6 alpha H,7 alpha H,8 alpha H)-austricin 8-O-beta-D-glucopyranoside (2), respectively. The structural identification of these compounds was mainly achieved by spectroscopic methods including 1D and 2D NMR techniques, and the structure of compound 1 was confirmed by a single crystal X-ray diffraction experiment. Compounds 1-2 were evaluated for cytotoxic activity in vitro against MCF-7, NCI-H460 and Hep-G2 cell lines, respectively. (c) 2014 Elsevier B.V. All rights reserved. |
| 关键词 | Artemisia Sieversiana Compositae Sesquiterpene Lignan Flavone Cytotoxic Activity |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 关键词[WOS] | CYTOTOXIC ACTIVITY ; CONSTITUENTS ; LACTONES ; LEAVES ; IDENTIFICATION ; DITERPENOIDS ; LIGNANS ; TOBACCO ; BARK |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000341346400006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://210.75.249.4/handle/363003/4194 |
| 专题 | 中国科学院西北高原生物研究所 |
| 作者单位 | 1.Southeast Univ, Dept Pharmaceut Engn, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810008, Peoples R China 3.Southeast Univ, Jiangsu Prov Hitech Key Lab Biomed Res, Nanjing 211189, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shi-Jun,Liao, Zhi-Xin,Liu, Chao,et al. Two new sesquiterpenes from Artemisia sieversiana[J]. FITOTERAPIA,2014,97:43-49. |
| APA | Liu, Shi-Jun,Liao, Zhi-Xin,Liu, Chao,Ji, Lan-Ju,&Sun, Hong-Fa.(2014).Two new sesquiterpenes from Artemisia sieversiana.FITOTERAPIA,97,43-49. |
| MLA | Liu, Shi-Jun,et al."Two new sesquiterpenes from Artemisia sieversiana".FITOTERAPIA 97(2014):43-49. |
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