Two New 2,3-Seco-Hopane Triterpene Derivatives from Megacodon stylophorus and Their Antiproliferative and Antimicrobial Activities

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	Two New 2,3-Seco-Hopane Triterpene Derivatives from Megacodon stylophorus and Their Antiproliferative and Antimicrobial Activities
	Liu, Chao 1,3; Liao, Zhi-Xin 1,3; Liu, Shi-Jun 1; Ji, Lan-Ju 2; Sun, Hong-Fa 2
	2014-07-01
发表期刊	PLANTA MEDICA
ISSN	0032-0943
卷号	80 期号:11 页码:936-941
文章类型	Article
摘要	Chemical investigation of the ethanol extract of the whole plant of Megacodon stylophorus led to the isolation and identification of two new secohopane triterpenoids, 2,3-seco-22(29)-hopene-2-carboxyl-3-aldehyde (1) and 2,3-seco-4(23),22 (29)-hopene-2-carboxyl-3-aldehyde (2), along with 10 known compounds, 3-12. All the isolates were reported from this plant for the first time. The structures of compounds 1 and 2 were determined by detailed analysis of their spectral data including 1D and 2D NMR. In addition, compound 1 was further analyzed by X-ray crystallography. Compounds 1-3 were evaluated for their in vitro anti-proliferative activities on HeLa, MCF-7, and Hep-G2 tumor cell lines. Compound 2 was active against the three cell lines with IC50 values of 3.6, 7.5, and 13.6 mu M, respectively, while compound 1 exhibited cytotoxicity on MCF-7 (IC50 14.0 mu M) and HeLa (IC50 18.2 mu M) cell lines. Antimicrobial activities of compounds 1-2 (minimum inhibitory concentration values in the range of 3.12-12.50 mg/mL) were also observed.; Chemical investigation of the ethanol extract of the whole plant of Megacodon stylophorus led to the isolation and identification of two new secohopane triterpenoids, 2,3-seco-22(29)-hopene-2-carboxyl-3-aldehyde (1) and 2,3-seco-4(23),22 (29)-hopene-2-carboxyl-3-aldehyde (2), along with 10 known compounds, 3-12. All the isolates were reported from this plant for the first time. The structures of compounds 1 and 2 were determined by detailed analysis of their spectral data including 1D and 2D NMR. In addition, compound 1 was further analyzed by X-ray crystallography. Compounds 1-3 were evaluated for their in vitro anti-proliferative activities on HeLa, MCF-7, and Hep-G2 tumor cell lines. Compound 2 was active against the three cell lines with IC50 values of 3.6, 7.5, and 13.6 mu M, respectively, while compound 1 exhibited cytotoxicity on MCF-7 (IC50 14.0 mu M) and HeLa (IC50 18.2 mu M) cell lines. Antimicrobial activities of compounds 1-2 (minimum inhibitory concentration values in the range of 3.12-12.50 mg/mL) were also observed.
关键词	Megacodon Stylophorus Gentianaceae Antiproliferative 2 Antimicrobial 3-seco-hopane Triterpenoids
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	CANCER-CELL LINES ; XANTHONE DERIVATIVES ; CENTAURIUM-ERYTHRAEA ; AERIAL PARTS ; STEROIDS ; RATS
收录类别	SCI
语种	英语
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000340577700012
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/4212
专题	中国科学院西北高原生物研究所
作者单位	1.Southeast Univ, Sch Chem & Chem Engn, Dept Pharmaceut Engn, Nanjing 211189, Jiangsu, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining, Peoples R China 3.Southeast Univ, Jiangsu Prov Hitech Key Lab Biomed Res, Nanjing 211189, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Liu, Chao,Liao, Zhi-Xin,Liu, Shi-Jun,et al. Two New 2,3-Seco-Hopane Triterpene Derivatives from Megacodon stylophorus and Their Antiproliferative and Antimicrobial Activities[J]. PLANTA MEDICA,2014,80(11):936-941.
APA	Liu, Chao,Liao, Zhi-Xin,Liu, Shi-Jun,Ji, Lan-Ju,&Sun, Hong-Fa.(2014).Two New 2,3-Seco-Hopane Triterpene Derivatives from Megacodon stylophorus and Their Antiproliferative and Antimicrobial Activities.PLANTA MEDICA,80(11),936-941.
MLA	Liu, Chao,et al."Two New 2,3-Seco-Hopane Triterpene Derivatives from Megacodon stylophorus and Their Antiproliferative and Antimicrobial Activities".PLANTA MEDICA 80.11(2014):936-941.