Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals

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	Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals
	Liu, Zhen 1,2; Wang, Wei 1,2; Zhang, Tong-Zuo 3; Li, Gong-Hua 1; He, Kai 1; Huang, Jing-Fei 1; Jiang, Xue-Long 1; Murphy, Robert W.1,4; Shi, Peng 1
	2014-02-07
发表期刊	PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
ISSN	0962-8452
卷号	281 期号:1776
文章类型	Article
摘要	Hibernating mammals need to be insensitive to acid in order to cope with conditions of high CO2; however, the molecular basis of acid tolerance remains largely unknown. The African naked mole-rat (Heterocephalus glaber) and hibernating mammals share similar environments and physiological features. In the naked mole-rat, acid insensitivity has been shown to be conferred by the functional motif of the sodium ion channel Na(V)1.7. There is now an opportunity to evaluate acid insensitivity in other taxa. In this study, we tested for functional convergence of Na(V)1.7 in 71 species of mammals, including 22 species that hibernate. Our analyses revealed a functional convergence of amino acid sequences, which occurred at least six times independently in mammals that hibernate. Evolutionary analyses determined that the convergence results from both parallel and divergent evolution of residues in the functional motif. Our findings not only identify the functional molecules responsible for acid insensitivity in hibernating mammals, but also open new avenues to elucidate the molecular underpinnings of acid insensitivity in mammals.; Hibernating mammals need to be insensitive to acid in order to cope with conditions of high CO2; however, the molecular basis of acid tolerance remains largely unknown. The African naked mole-rat (Heterocephalus glaber) and hibernating mammals share similar environments and physiological features. In the naked mole-rat, acid insensitivity has been shown to be conferred by the functional motif of the sodium ion channel Na(V)1.7. There is now an opportunity to evaluate acid insensitivity in other taxa. In this study, we tested for functional convergence of Na(V)1.7 in 71 species of mammals, including 22 species that hibernate. Our analyses revealed a functional convergence of amino acid sequences, which occurred at least six times independently in mammals that hibernate. Evolutionary analyses determined that the convergence results from both parallel and divergent evolution of residues in the functional motif. Our findings not only identify the functional molecules responsible for acid insensitivity in hibernating mammals, but also open new avenues to elucidate the molecular underpinnings of acid insensitivity in mammals.
关键词	Scn9a Adaptation Convergent Evolution Acid Insensitivity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	SODIUM-CHANNEL ; ADAPTIVE EVOLUTION ; TEMPERATURE ; ACCURACY ; TORPOR ; MUSCLE ; GENES ; BATS ; RAT ; PH
收录类别	SCI
语种	英语
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Environmental Sciences & Ecology ; Evolutionary Biology
WOS类目	Biology ; Ecology ; Evolutionary Biology
WOS记录号	WOS:000332381500026
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/4253
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810008, Peoples R China 4.Royal Ontario Museum, Ctr Biodivers & Conservat Biol, Toronto, ON M5S 2C6, Canada
推荐引用方式 GB/T 7714	Liu, Zhen,Wang, Wei,Zhang, Tong-Zuo,et al. Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals[J]. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES,2014,281(1776).
APA	Liu, Zhen.,Wang, Wei.,Zhang, Tong-Zuo.,Li, Gong-Hua.,He, Kai.,...&Shi, Peng.(2014).Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals.PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES,281(1776).
MLA	Liu, Zhen,et al."Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals".PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 281.1776(2014).

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