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| Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balt, on fatty acid synthase and human breast cancer cells | |
| Li, Ping1; Tian, Weixi1; Wang, Xiaoyan2; Ma, Xiaofeng1 | |
| 2014-02-01 | |
| 发表期刊 | FOOD & FUNCTION
 |
| ISSN | 2042-6496 |
| 卷号 | 5期号:2页码:251-256 |
| 文章类型 | Article |
| 摘要 | Fatty acid synthase (FAS) has attracted more and more attention as a potential target for cancer treatment. Natural FAS inhibitors are emerging as potential therapeutic agents to treat cancer. Rheum tanguticum Maxim. ex Bait. (rhubarb) is a traditional Chinese nutritional food and has been reported to possess a variety of biological activities, including the ability to induce the apoptosis of cancer cells. This study indicates that desoxyrhaponticin (DC) and rhaponticin (RC), two stilbene glycosides from rhubarb, could be considered as promising FAS inhibitors. We found that both DC and RC could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells. In addition, the apoptotic effect of DC on human cancer cells was announced for the first time. Since FAS plays a key role in the biosynthesis pathway of fatty acids in cancer cells, these findings suggest that DC has potential applications in the prevention and treatment of cancer.; Fatty acid synthase (FAS) has attracted more and more attention as a potential target for cancer treatment. Natural FAS inhibitors are emerging as potential therapeutic agents to treat cancer. Rheum tanguticum Maxim. ex Bait. (rhubarb) is a traditional Chinese nutritional food and has been reported to possess a variety of biological activities, including the ability to induce the apoptosis of cancer cells. This study indicates that desoxyrhaponticin (DC) and rhaponticin (RC), two stilbene glycosides from rhubarb, could be considered as promising FAS inhibitors. We found that both DC and RC could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells. In addition, the apoptotic effect of DC on human cancer cells was announced for the first time. Since FAS plays a key role in the biosynthesis pathway of fatty acids in cancer cells, these findings suggest that DC has potential applications in the prevention and treatment of cancer. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 关键词[WOS] | PARTHENOCISSUS-TRICUSPIDATA ; POLYGONUM-MULTIFLORUM ; RHUBARB ; EXPRESSION ; REQUIREMENTS ; NEOPLASIA ; CARCINOMA ; RHIZOMA ; ENZYME ; CHINA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Biochemistry & Molecular Biology ; Food Science & Technology |
| WOS类目 | Biochemistry & Molecular Biology ; Food Science & Technology |
| WOS记录号 | WOS:000331432400008 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://210.75.249.4/handle/363003/4255 |
| 专题 | 中国科学院西北高原生物研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ping,Tian, Weixi,Wang, Xiaoyan,et al. Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balt, on fatty acid synthase and human breast cancer cells[J]. FOOD & FUNCTION,2014,5(2):251-256. |
| APA | Li, Ping,Tian, Weixi,Wang, Xiaoyan,&Ma, Xiaofeng.(2014).Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balt, on fatty acid synthase and human breast cancer cells.FOOD & FUNCTION,5(2),251-256. |
| MLA | Li, Ping,et al."Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balt, on fatty acid synthase and human breast cancer cells".FOOD & FUNCTION 5.2(2014):251-256. |
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