A Review on Differential Isotope-coded Derivatization Reagents for LC-API-MS Analyses

NWIPB OpenIR

	A Review on Differential Isotope-coded Derivatization Reagents for LC-API-MS Analyses
	Sun, Zhiwei 1; Sun, Haiyi 1; Li, Hongtao 1; You, Jinmao 1,2; Xia, Lian 1
	2014
发表期刊	CURRENT ANALYTICAL CHEMISTRY
ISSN	1573-4110
卷号	10 期号:3 页码:381-392
文章类型	Review
摘要	High-performance liquid chromatography coupling with atmospheric pressure ionization mass spectrometry (LC-API-MS) has been widely used in the pharmaceutical industry, clinical research, environmental science, metabolomics studies and so on. However, LC-API-MS often suffers from the matrix effect in its applications in complex samples. Matrix effects can heavily affect reproducibility, linearity, and accuracy of the method leading to erroneous quantitation. The use of isotope-labeled analyte as internal standards provides an efficient solution to overcome matrix effects in LC-API-MS analysis. However, the isotope-labeled standards are expensive and not always available, especially in the analysis of large numbers of analytes. In recent years, the stable isotope-coded derivatization reagents, as an alternative way, have been used to quantify small molecules in LC-API-MS analysis of complex samples. In this review, an overview of differential isotope-coded derivatization reagents is presented, focusing on the applications to low molecular weight compounds by LC-API-MS. The recently reported isotope-coded derivatization reagents were summarized in category of their target analytes, specifically peptides, amines, phenols, carboxylic acids, aldehyde or ketone, saccharides and thiols. It indicates that isotope-labeled derivatization reagent would have an increasingly wide range of applications in the LC-API-MS analysis.; High-performance liquid chromatography coupling with atmospheric pressure ionization mass spectrometry (LC-API-MS) has been widely used in the pharmaceutical industry, clinical research, environmental science, metabolomics studies and so on. However, LC-API-MS often suffers from the matrix effect in its applications in complex samples. Matrix effects can heavily affect reproducibility, linearity, and accuracy of the method leading to erroneous quantitation. The use of isotope-labeled analyte as internal standards provides an efficient solution to overcome matrix effects in LC-API-MS analysis. However, the isotope-labeled standards are expensive and not always available, especially in the analysis of large numbers of analytes. In recent years, the stable isotope-coded derivatization reagents, as an alternative way, have been used to quantify small molecules in LC-API-MS analysis of complex samples. In this review, an overview of differential isotope-coded derivatization reagents is presented, focusing on the applications to low molecular weight compounds by LC-API-MS. The recently reported isotope-coded derivatization reagents were summarized in category of their target analytes, specifically peptides, amines, phenols, carboxylic acids, aldehyde or ketone, saccharides and thiols. It indicates that isotope-labeled derivatization reagent would have an increasingly wide range of applications in the LC-API-MS analysis.
关键词	Atmospheric Pressure Ionization High Performance Liquid Chromatography Isotope-coded Derivatization Reagent Mass Spectrometry
WOS标题词	Science & Technology ; Physical Sciences
关键词[WOS]	CHROMATOGRAPHY-MASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; QUANTITATIVE PROTEOMICS ; RELATIVE QUANTIFICATION ; ELECTROSPRAY-IONIZATION ; ESI-MS ; SULFONAMIDE ANTIBACTERIALS ; CONTAINING METABOLITES ; INTERNAL STANDARD ; LABELING REAGENT
收录类别	SCI
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
WOS记录号	WOS:000337253600011
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/4276
专题	中国科学院西北高原生物研究所
作者单位	1.Qufu Normal Univ, Key Lab Life Organ Anal Shandong Prov, Qufu 273165, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810008, Peoples R China
推荐引用方式 GB/T 7714	Sun, Zhiwei,Sun, Haiyi,Li, Hongtao,et al. A Review on Differential Isotope-coded Derivatization Reagents for LC-API-MS Analyses[J]. CURRENT ANALYTICAL CHEMISTRY,2014,10(3):381-392.
APA	Sun, Zhiwei,Sun, Haiyi,Li, Hongtao,You, Jinmao,&Xia, Lian.(2014).A Review on Differential Isotope-coded Derivatization Reagents for LC-API-MS Analyses.CURRENT ANALYTICAL CHEMISTRY,10(3),381-392.
MLA	Sun, Zhiwei,et al."A Review on Differential Isotope-coded Derivatization Reagents for LC-API-MS Analyses".CURRENT ANALYTICAL CHEMISTRY 10.3(2014):381-392.