In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom.

NWIPB OpenIR

	In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom.
	Zhou, Wenna ; Xu, Heng ; Luan, Guangxiang ; Wang, HongLun ; Wang, Xiaoyan ; Ji, Mingkai
	2016
发表期刊	SKIN PHARMACOLOGY AND PHYSIOLOGY
摘要	Aim: The objective of this study was to evaluate the effects of seed oil of Caragana korshinskii Kom. against Trichophyton mentagrophytes on an in vivo guinea pig model of dermatophytosis. Methods: The skin of albino guinea pigs was infected with T. mentagrophytes, and the animals were divided into five groups: negative control (NC group), positive control (PC group), vehicle control, CK50% group (received topical 50% seed oil of C korshinskii), and CK100% group (received topical 100% seed oil of C korshinskii). Evaluation of clinical efficacy was performed 72 h after the completion of a 10-day treatment regimen. Skin biopsy samples were processed for histopathological examination. Results: The infected untreated control guinea pigs showed patches of hair loss and ulcerated or scaly skin. Lower clinical scores indicate improved efficacy compared with NC. The lesion scores significantly declined in the CK50%, CK100%, and PC groups in comparison with the NC group. The CK50% group (45.31%) and the CK100% group (75%) showed clinical efficacy compared with the PC group (78.13%). In addition, no fungal elements, inflammation, or tissue destruction was observed in any of the PAS-stained sections of the infected skin in the groups treated with CK100% or 1% terbinafine. Conclusion: Seed oil of C. korshinskii demonstrated high antifungal efficacy in experimental dermatophytosis. (C) 2016 S. Karger AG, Basel
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/43263
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhou, Wenna,Xu, Heng,Luan, Guangxiang,et al. In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom.[J]. SKIN PHARMACOLOGY AND PHYSIOLOGY,2016.
APA	Zhou, Wenna,Xu, Heng,Luan, Guangxiang,Wang, HongLun,Wang, Xiaoyan,&Ji, Mingkai.(2016).In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom..SKIN PHARMACOLOGY AND PHYSIOLOGY.
MLA	Zhou, Wenna,et al."In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom.".SKIN PHARMACOLOGY AND PHYSIOLOGY (2016).