Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro

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	Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro
	Yuan, Zhenzhen ; Luan, Guangxiang ; Wang, Zhenhua ; Hao, Xueyan ; Li, Ji ; Suo, Yourui ; Li, Gang ; Wang, Honglun
	2017-06-01
发表期刊	CHEMISTRY & BIODIVERSITY
摘要	Potentilla parvifolia FISCH. (Rosaceae) is a traditional medicinal plant in P. R. China. In this study, seven flavonoids, ayanin (1), tricin (2), quercetin (3), tiliroside (4), miquelianin (5), isoquercitrin (6), and astragalin (7), were separated and purified from ethyl acetate extractive fractions from ethanol extracts of P. parvifolia using a combination of sevaral chromatographic methods. The human neuroblastoma SH-SY5Y cells were differentiated with all trans-retinoic acid and treated with okadaic acid to induce tau protein phosphorylation and synaptic atrophy, which could establish an Alzheimer's disease cell model. The neuroprotective effects of these flavonoids in cellular were evaluated in vitro by this cell model. Results from the Western blot and morphology analysis suggested that compounds 3 and 4 had the better neuroprotective effects.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/43529
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Yuan, Zhenzhen,Luan, Guangxiang,Wang, Zhenhua,et al. Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro[J]. CHEMISTRY & BIODIVERSITY,2017.
APA	Yuan, Zhenzhen.,Luan, Guangxiang.,Wang, Zhenhua.,Hao, Xueyan.,Li, Ji.,...&Wang, Honglun.(2017).Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro.CHEMISTRY & BIODIVERSITY.
MLA	Yuan, Zhenzhen,et al."Flavonoids from Potentilla parvifolia FISCH and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells in vitro".CHEMISTRY & BIODIVERSITY (2017).