Synthesis and antimicrobial activities of novel peptide deformylase inhibitors

NWIPB OpenIR

	Synthesis and antimicrobial activities of novel peptide deformylase inhibitors
	Yin, Ling ; Xu, Wei-Ren ; Wang, Zhi-Guo ; Zhang, Da-Tong ; Jia, Jiong ; Ge, Yan-Qing ; Li, Yan ; Wang, Jian-Wu
	2010
发表期刊	ARKIVOC ; Yin, L; Xu, WR; Wang, ZG; Zhang, DT; Jia, JO; Ge, YQ; Li, Y; Wang, JW.Synthesis and antimicrobial activities of novel peptide deformylase inhibitors,ARKIVOC,2010,():196-205
摘要	A new series of N-formylhydroxylamine compounds were designed, optimized with the AutoDock 4.0.1 to investigate the interactions between the target compounds and the amino acid residues of the Escherichia coli PDF center dot Ni enzyme, and then synthesized through multi-step sequence starting from diethyl malonate. The structures of the compounds were characterized on the basis of spectral (FT-IR, 1H NMR and mass) analysis. All the synthesized compounds have been screened for their antimicrobial activities. It was found that the compounds 11c, 11d, 11f and 11g exhibited potent inhibitory activity against S. aureus in vitro.; A new series of N-formylhydroxylamine compounds were designed, optimized with the AutoDock 4.0.1 to investigate the interactions between the target compounds and the amino acid residues of the Escherichia coli PDF center dot Ni enzyme, and then synthesized through multi-step sequence starting from diethyl malonate. The structures of the compounds were characterized on the basis of spectral (FT-IR, 1H NMR and mass) analysis. All the synthesized compounds have been screened for their antimicrobial activities. It was found that the compounds 11c, 11d, 11f and 11g exhibited potent inhibitory activity against S. aureus in vitro.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/46032
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Yin, Ling,Xu, Wei-Ren,Wang, Zhi-Guo,et al. Synthesis and antimicrobial activities of novel peptide deformylase inhibitors[J]. ARKIVOC, Yin, L; Xu, WR; Wang, ZG; Zhang, DT; Jia, JO; Ge, YQ; Li, Y; Wang, JW.Synthesis and antimicrobial activities of novel peptide deformylase inhibitors,ARKIVOC,2010,():196-205,2010.
APA	Yin, Ling.,Xu, Wei-Ren.,Wang, Zhi-Guo.,Zhang, Da-Tong.,Jia, Jiong.,...&Wang, Jian-Wu.(2010).Synthesis and antimicrobial activities of novel peptide deformylase inhibitors.ARKIVOC.
MLA	Yin, Ling,et al."Synthesis and antimicrobial activities of novel peptide deformylase inhibitors".ARKIVOC (2010).