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Hypoxia effects on hypothalamic corticotropin-releasing hormone and anterior pituitary cAMP | |
Chen, Z ; Du, JZ | |
1996-11-01 | |
发表期刊 | ACTA PHARMACOLOGICA SINICA |
摘要 | AIM: To study the effects of acute and chronic hypoxia on hypothalamus-anterior pituitary-adrenocortex axis. METHODS: Rats and pikas were exposed to different altitude and periods. Animals were injected with CRH, Arg and NE in the third ventricle of the brain of rats. RESULTS: Anterior pituitary cAMP and plasma corticosterone levels of rats obviously increased during 1 h of hypoxia. cAMP was increased from 2.23 +/- 0.13 of control group to 7.7 +/- 0.7 of 5 km and 13.4 +/- 1.9 nmol/g wet tissue of 8 km, respectively. icv CRH, Arg and NE all activated HPA axis. The effects of CRH were most potent. CRH 2 mu L 0.75 nmol icv increased anterior pituitary of cAMP from 3.5 +/- 0.4 of control to 22.4 +/- 2.2 nmol/kg wet tissue. Stimulating altitude of 5000 m resulted in a 16.9 % decrease in corticosterone level (P < 0.05), 8000 m resulted in a 47.5 % decrease (P < 0.01) after hypoxia for 25 d. Hypoxia did not activate HPA axis in pikas. CONCLUSION: 1) Hypoxia stress activates the secretion of corticotrophin (ACTH) via cAMP; 2) Adrenocotical function of rats decays during chronic hypoxia; 3) Arg and NE regulate the secretion of plasma corticosterone and synthesis of pituitary cAMP at the hypothalamus level; 4) Hypoxia tolerance of the pika was high. |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/49217 |
专题 | 中国科学院西北高原生物研究所 |
推荐引用方式 GB/T 7714 | Chen, Z,Du, JZ. Hypoxia effects on hypothalamic corticotropin-releasing hormone and anterior pituitary cAMP[J]. ACTA PHARMACOLOGICA SINICA,1996. |
APA | Chen, Z,&Du, JZ.(1996).Hypoxia effects on hypothalamic corticotropin-releasing hormone and anterior pituitary cAMP.ACTA PHARMACOLOGICA SINICA. |
MLA | Chen, Z,et al."Hypoxia effects on hypothalamic corticotropin-releasing hormone and anterior pituitary cAMP".ACTA PHARMACOLOGICA SINICA (1996). |
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