NWIPB OpenIR
Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles
Qu, Fei ; Liu, Yanqun ; Lao, Haili ; Wang, Yaping ; You, Jinmao
2017-10-07
发表期刊NEW JOURNAL OF CHEMISTRY
摘要Herein, a new colorimetric strategy based on polymer nanoparticles (PNPs) and Au nanoparticles (AuNPs) is developed to detect heparin (Hep). The cationic PNPs can directly induce the aggregation of AuNPs, which are stabilized by negatively charged coating of citrate ions, and hence the absorption peak of AuNPs moves to 675 nm corresponding with a color change from wine red to blue. However, the negatively charged Hep competes with AuNPs and binds to PNPs, hindering the interaction between PNPs and AuNPs. As a result, the absorption band of AuNPs blue shifts and the color turns to red again. The reaction can be completed within 10 min, and the color variation produced by 150 nM of Hep can be distinguished by the naked eye. In addition, this strategy also shows good selectivity and sensitivity, and the linear range of Hep is from 10 to 400 nM with detection limit of 2.5 nM. Finally, this colorimetric assay has been applied to measure Hep in Hep sodium injection and human serum samples with satisfactory recoveries.
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/53739
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Qu, Fei,Liu, Yanqun,Lao, Haili,et al. Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles[J]. NEW JOURNAL OF CHEMISTRY,2017.
APA Qu, Fei,Liu, Yanqun,Lao, Haili,Wang, Yaping,&You, Jinmao.(2017).Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles.NEW JOURNAL OF CHEMISTRY.
MLA Qu, Fei,et al."Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles".NEW JOURNAL OF CHEMISTRY (2017).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Qu, Fei]的文章
[Liu, Yanqun]的文章
[Lao, Haili]的文章
百度学术
百度学术中相似的文章
[Qu, Fei]的文章
[Liu, Yanqun]的文章
[Lao, Haili]的文章
必应学术
必应学术中相似的文章
[Qu, Fei]的文章
[Liu, Yanqun]的文章
[Lao, Haili]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。