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Isolation, purification and identification of antioxidants from Lepidium latifolium extracts
Yuan Xiang ; Wang Haixia ; Mei Lijuan ; Tao Yanduo
2018
发表期刊MEDICINAL CHEMISTRY RESEARCH
摘要Antioxidant potencies of an ethanolic extract and its components from Lepidium latifolium were investigated. In this study, we found that the ethyl acetate soluble fraction of L. latifolium was a rich source of antioxidant, resulting from its high total phenolic content. To determine the antioxidant components of the ethyl acetate fraction, a bioassay-guided fractionation approach using 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate), and ferric reducing antioxidant power assays were conducted. Nine compounds were isolated and their structures were identified by MS and NMR spectral data and comparison to reported data. They are Quercetin-3-O-beta-d-sophoroside-7-O-alpha-l-rhamnoside (1), Apetalumoside B6 (2), Kaempferol-3-O-beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranoside-7-O-beta-D-glucopyranoside (3), Kaempferol-7-O-alpha-l-rhamnopyranoside (4), Kaempferol-3-O-beta-D-glucopyranoside-7-O-alpha-l-rhamnopyranoside (5), Kaempferol-3-O-(2-O-feruloyl-beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranoside)-7-O-glucopyranoside (6), Kaempferol-3-O-beta-D-sophoroside-7-O-alpha-l-rhamnoside (7), Kaempferol-3-O-robinoside-7-O-(2aEuro(3)aEuro(3)-(E)-feruloyl)-sophoroside (8), Quercetin-3-O-(2,6-di-O-beta-D-glucopyranosyl)-beta-D-glucopyranoside-7-O-alpha-l-rhamnopyranoside (9), compounds 1, 2, 4, and 8 had potent free radical scavenging activity. The IC50 values of these compounds were 9.8-12.3 and 7.4-31.4 mu g/mL in DPPH and ABTS assays, respectively. The results indicate that L. latifolium is a potential natural source of antioxidants to treat several diseases related to oxidant by-products of human metabolism.
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/54326
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Yuan Xiang,Wang Haixia,Mei Lijuan,et al. Isolation, purification and identification of antioxidants from Lepidium latifolium extracts[J]. MEDICINAL CHEMISTRY RESEARCH,2018.
APA Yuan Xiang,Wang Haixia,Mei Lijuan,&Tao Yanduo.(2018).Isolation, purification and identification of antioxidants from Lepidium latifolium extracts.MEDICINAL CHEMISTRY RESEARCH.
MLA Yuan Xiang,et al."Isolation, purification and identification of antioxidants from Lepidium latifolium extracts".MEDICINAL CHEMISTRY RESEARCH (2018).
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