Knowledge Management System of Northwest Institute of Plateau Biology, CAS
| Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry | |
| Wang, Hailiang1; Gao, Tingting2,3; Du, Yuzhi2,3; Yang, Hongxia2,3; Wei, Lixin2,3; Bi, Hongtao2,4; Ni, Weihua5 | |
| 2015-10-20 | |
| 发表期刊 | CARBOHYDRATE POLYMERS
 |
| 卷号 | 131页码:288-296 |
| 文章类型 | Article |
| 摘要 | Our previous study isolated an anti-fatigue polysaccharide (HRWP) from the Hippophae rhamnoides berry. In this study, using ion-exchange chromatography and gel filtration chromatography in turn, a watersoluble homogenous polysaccharide HRWP-A was isolated from HRWP. Structural analysis determined that HRWP-A was a polysaccharide with repeating units of (1 -> 4)-beta-D-galactopyranosyluronic residues, of which 85.16% were esterified with methyl groups. An antitumor activity assay showed that HRWP-A could significantly inhibit the Lewis lung carcinoma (LLC) growth in tumor-bearing mice. Further experiments suggested that the antitumor effect of HRWP-A might be mediated through immunostimulating activity, as it enhances the lymphocyte proliferation, augments the macrophage activities, as well as promoting NK cell activity and CTL cytotoxicity in tumor-bearing mice. To our knowledge, this is the first report on a natural antitumor high-methoxyl homogalacturonan pectin from the H. rhamnoides berry-a compound that acts as a potential immunostimulant and anticancer adjuvant. (C) 2015 Elsevier Ltd. All rights reserved.; Our previous study isolated an anti-fatigue polysaccharide (HRWP) from the Hippophae rhamnoides berry. In this study, using ion-exchange chromatography and gel filtration chromatography in turn, a watersoluble homogenous polysaccharide HRWP-A was isolated from HRWP. Structural analysis determined that HRWP-A was a polysaccharide with repeating units of (1 -> 4)-beta-D-galactopyranosyluronic residues, of which 85.16% were esterified with methyl groups. An antitumor activity assay showed that HRWP-A could significantly inhibit the Lewis lung carcinoma (LLC) growth in tumor-bearing mice. Further experiments suggested that the antitumor effect of HRWP-A might be mediated through immunostimulating activity, as it enhances the lymphocyte proliferation, augments the macrophage activities, as well as promoting NK cell activity and CTL cytotoxicity in tumor-bearing mice. To our knowledge, this is the first report on a natural antitumor high-methoxyl homogalacturonan pectin from the H. rhamnoides berry-a compound that acts as a potential immunostimulant and anticancer adjuvant. (C) 2015 Elsevier Ltd. All rights reserved. |
| 关键词 | Homogalacturonan Hippophae Rhamnoides L. Antitumor Activity Immunostimulating Activity |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 关键词[WOS] | WATER-SOLUBLE POLYSACCHARIDE ; TUMOR-BEARING MICE ; STRUCTURAL-CHARACTERIZATION ; PECTIC POLYSACCHARIDES ; BIOLOGICAL-ACTIVITIES ; FRUITS ; ROOTS ; ACIDS ; TEA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Chemistry ; Polymer Science |
| WOS类目 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| WOS记录号 | WOS:000361183600035 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://210.75.249.4/handle/363003/5494 |
| 专题 | 中国科学院西北高原生物研究所 |
| 作者单位 | 1.Jilin Univ, Hosp 2, Dept Neurosurg, Changchun 130033, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining 810008, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Lab Tibetan Med Res, Xining 810008, Peoples R China 4.Chinese Acad Sci, Northwest Inst Plateau Biol, Lab Adaptat & Evolut Plateau Biota, Xining 810008, Peoples R China 5.Jilin Univ, Dept Immunol, Coll Basic Med Sci, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hailiang,Gao, Tingting,Du, Yuzhi,et al. Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry[J]. CARBOHYDRATE POLYMERS,2015,131:288-296. |
| APA | Wang, Hailiang.,Gao, Tingting.,Du, Yuzhi.,Yang, Hongxia.,Wei, Lixin.,...&Ni, Weihua.(2015).Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry.CARBOHYDRATE POLYMERS,131,288-296. |
| MLA | Wang, Hailiang,et al."Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry".CARBOHYDRATE POLYMERS 131(2015):288-296. |
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