Knowledge Management System of Northwest Institute of Plateau Biology, CAS
| Chemical constituents of Swertia mussotii and their anti-hepatitis B virus activity | |
| Cao, Tuan-Wu1; Geng, Chang-An1; Ma, Yun-Bao1; Zhang, Xue-Mei1; Zhou, Jun1; Tao, Yan-Duo2; Chen, Ji-Jun1 | |
| 2015-04-01 | |
| 发表期刊 | FITOTERAPIA
 |
| 卷号 | 102页码:15-22 |
| 文章类型 | Article |
| 摘要 | Three new secoiridoid aglycones of (-)-swermusic acid A (1) and B (3), and (-)-swerimuslatone A (2), and four new secoiridoid glycosides of 6'-O-formylsweroside (4),6'-O-formylgentiopicroside (5), 6'-O-acetylamarogentin (6) and 6'-O-acetylamaronitidin (7), along with 40 known compounds (8-47) were isolated from Swertia mussotii. Their structures were elucidated on the basis of extensive spectroscopic analyses including MS, IR, UV, 1D- and 2D-NMR. Forty-five compounds from S. mussotii were evaluated for their anti-HBV activity on the HepG 2.2.15 cell line in vitro inhibiting the secretions of HBsAg and HBeAg, as well as HBV DNA replication. Six of the nine phenols 26-29,31 and 32 exhibited activities inhibiting HBsAg and HBeAg secretion with IC50 values from 0.23 to 5.18 mM, and HBV DNA replication with IC50 values from <0.06 to 2.62 mM. Moreover, isooriention (45) displayed significant anti-HBV activities against secretions of HBsAg and HBeAg with IC50 value of 0.79 and 1.12 mM, as well as HBV DNA replication with IC50 value of 0.02 mM. (C) 2015 Elsevier B.V. All rights reserved.; Three new secoiridoid aglycones of (-)-swermusic acid A (1) and B (3), and (-)-swerimuslatone A (2), and four new secoiridoid glycosides of 6'-O-formylsweroside (4),6'-O-formylgentiopicroside (5), 6'-O-acetylamarogentin (6) and 6'-O-acetylamaronitidin (7), along with 40 known compounds (8-47) were isolated from Swertia mussotii. Their structures were elucidated on the basis of extensive spectroscopic analyses including MS, IR, UV, 1D- and 2D-NMR. Forty-five compounds from S. mussotii were evaluated for their anti-HBV activity on the HepG 2.2.15 cell line in vitro inhibiting the secretions of HBsAg and HBeAg, as well as HBV DNA replication. Six of the nine phenols 26-29,31 and 32 exhibited activities inhibiting HBsAg and HBeAg secretion with IC50 values from 0.23 to 5.18 mM, and HBV DNA replication with IC50 values from <0.06 to 2.62 mM. Moreover, isooriention (45) displayed significant anti-HBV activities against secretions of HBsAg and HBeAg with IC50 value of 0.79 and 1.12 mM, as well as HBV DNA replication with IC50 value of 0.02 mM. (C) 2015 Elsevier B.V. All rights reserved. |
| 关键词 | Swertia Mussotii Gentianaceae Chemical Constituents (-)-swermusic Acid a And b (-)-swerimuslatone a Anti-hbv Activity |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 关键词[WOS] | SECOIRIDOID GLYCOSIDES ; GENTIANA ; TRITERPENOIDS ; DISEASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000353742600003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://210.75.249.4/handle/363003/5567 |
| 专题 | 中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Res Ctr Biol Resources Qinghai Tibet Plateau, Xining 810001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Tuan-Wu,Geng, Chang-An,Ma, Yun-Bao,et al. Chemical constituents of Swertia mussotii and their anti-hepatitis B virus activity[J]. FITOTERAPIA,2015,102:15-22. |
| APA | Cao, Tuan-Wu.,Geng, Chang-An.,Ma, Yun-Bao.,Zhang, Xue-Mei.,Zhou, Jun.,...&Chen, Ji-Jun.(2015).Chemical constituents of Swertia mussotii and their anti-hepatitis B virus activity.FITOTERAPIA,102,15-22. |
| MLA | Cao, Tuan-Wu,et al."Chemical constituents of Swertia mussotii and their anti-hepatitis B virus activity".FITOTERAPIA 102(2015):15-22. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Cao-2015-Chemical co（447KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论