Chemical Components, Mercury Coordination Structure and Micro-Morphology of Tibetan Medicine Zuotai

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	Chemical Components, Mercury Coordination Structure and Micro-Morphology of Tibetan Medicine Zuotai
	Li Cen 1,6; Zhan-dui 2; Leng-ben-cai-rang 3; Sang-lao 3; Suo-lang 4; Duo-jie-la-dan 5; Duo-ji 2; Du Yu-zhi 1; Li Lin-shuai 1,6; Zhang Ming 1,6; Yang Hong-xia 1,6; Bi Hong-tao 1; Wei Li-xin 1
	2015-04-01
发表期刊	SPECTROSCOPY AND SPECTRAL ANALYSIS
卷号	35 期号:4 页码:1072-1078
文章类型	Article
摘要	In order to reveal the chemical substance basis of pharmacodynamic effects of Zuotai, energy dispersive spectrometry of X-ray (EDX), X-ray fluorescence spectroscopy (XRF), synchrotron radiation X-ray absorption fine structure (SR-XAFS) X-ray diffraction (XRD), scanning electron microscope (SEM) and atomic force microscope (AFM) were used to analyze the elements, the chemical valence and local structure of mercury, and the chemical phase composition and micro-morphology of Zuotai. EDX and XRF analysis shows that the main elements in Zuotai are Hg and S, with some other minor elements, such as O, Fe, Al, Cu, K, Ag, Ca, Mg etc. SR-XAFS analysis shows that: the oxidation state of mercury in Zuotai is divalence, its neighbor atoms are S, and its coordination number is four. XRD assay found that beta-HgS (cubic, F-43m 216) and S8 (orthorhombic, Fddd 70) are the main phase compositions in Zuotai. Besides, it also has a small amount of C (hexagonal, P63/mmc 194), Fe1.05S0.95 (hexagonal, P63/mmc 194), Cu6S6 (hexagonal, P63/mmc 194), Cu1.8S (cubic, F-43m 216) and so on. And it was found that the crystallinity of Zuotai is about 59%, and the amorphous morphology substance in it is about 41%. SEM and AFM detection suggests that Zuotai is a kind of ancient micro-nano drug, and its particle size is mainly in the range of 100 similar to 600 nm, even less than 100 nm, which commonly further aggregate into several to 30 mu m loose amorphous particles. In summary, the present study elucidated physicochemical characterization(elements composition, coordination information of mercury, phase composition and micro-morphology) of Zuotai, and it will play a positive role in promoting the interpretation of this mysterious drug.; In order to reveal the chemical substance basis of pharmacodynamic effects of Zuotai, energy dispersive spectrometry of X-ray (EDX), X-ray fluorescence spectroscopy (XRF), synchrotron radiation X-ray absorption fine structure (SR-XAFS) X-ray diffraction (XRD), scanning electron microscope (SEM) and atomic force microscope (AFM) were used to analyze the elements, the chemical valence and local structure of mercury, and the chemical phase composition and micro-morphology of Zuotai. EDX and XRF analysis shows that the main elements in Zuotai are Hg and S, with some other minor elements, such as O, Fe, Al, Cu, K, Ag, Ca, Mg etc. SR-XAFS analysis shows that: the oxidation state of mercury in Zuotai is divalence, its neighbor atoms are S, and its coordination number is four. XRD assay found that beta-HgS (cubic, F-43m 216) and S8 (orthorhombic, Fddd 70) are the main phase compositions in Zuotai. Besides, it also has a small amount of C (hexagonal, P63/mmc 194), Fe1.05S0.95 (hexagonal, P63/mmc 194), Cu6S6 (hexagonal, P63/mmc 194), Cu1.8S (cubic, F-43m 216) and so on. And it was found that the crystallinity of Zuotai is about 59%, and the amorphous morphology substance in it is about 41%. SEM and AFM detection suggests that Zuotai is a kind of ancient micro-nano drug, and its particle size is mainly in the range of 100 similar to 600 nm, even less than 100 nm, which commonly further aggregate into several to 30 mu m loose amorphous particles. In summary, the present study elucidated physicochemical characterization(elements composition, coordination information of mercury, phase composition and micro-morphology) of Zuotai, and it will play a positive role in promoting the interpretation of this mysterious drug.
关键词	Tibetan Medicine Zuotai(Gtso Thal) Heavy Meta Mercury Chemical Form
WOS标题词	Science & Technology ; Technology
收录类别	SCI
语种	英语
WOS研究方向	Spectroscopy
WOS类目	Spectroscopy
WOS记录号	WOS:000352926900042
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/5569
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Pharmacol & Safety Evaluat Key Lab Tibetan Med Qi, Xining 810001, Peoples R China 2.Tibetan Tradit Med Coll, Lhasa 850000, Peoples R China 3.Gansu Prov Acad Tibetan Med, Hezuo 747000, Peoples R China 4.Aba Prefecture Tibetan Med Hosp, Maerkang 624000, Peoples R China 5.Qinghai Prov Tibetan Med Hosp, Xining 810007, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li Cen,Zhan-dui,Leng-ben-cai-rang,et al. Chemical Components, Mercury Coordination Structure and Micro-Morphology of Tibetan Medicine Zuotai[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2015,35(4):1072-1078.
APA	Li Cen.,Zhan-dui.,Leng-ben-cai-rang.,Sang-lao.,Suo-lang.,...&Wei Li-xin.(2015).Chemical Components, Mercury Coordination Structure and Micro-Morphology of Tibetan Medicine Zuotai.SPECTROSCOPY AND SPECTRAL ANALYSIS,35(4),1072-1078.
MLA	Li Cen,et al."Chemical Components, Mercury Coordination Structure and Micro-Morphology of Tibetan Medicine Zuotai".SPECTROSCOPY AND SPECTRAL ANALYSIS 35.4(2015):1072-1078.