Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments

doi:10.1111/1749-4877.12178

NWIPB OpenIR

	Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments
	Guo, Xinyi 1,2; Xie, Ling 1,2; Zhang, Xuze 3; Ji, Yinfa 1; Chen, Juan 1,2; Pang, Bo 1,2; Xu, Yongtao 4; Qi, Delin 5; Guo, Songchang 1
	2016-03-01
发表期刊	INTEGRATIVE ZOOLOGY
卷号	11 期号:2 页码:86-97
文章类型	Article
摘要	Fishes harbor a huge resource of phenotypic diversity and are useful for understanding the genetic basis of morphological variation. However, it is difficult to transfer classical genetic mapping to most non-model species. In this study, we performed a comparative sequence analysis of Fgfr1a to first interpret the evolution of this candidate scale-loss gene in 15 schizothoracine fishes with various scale phenotypes. While considerable amino acid (AA) substitutions were observed, molecular evolution analysis indicates that the overall coding regions were subject to functional constraint. We also identified extra copies of Fgfr1a in 4 scale-loss fishes and detected accelerated evolution in one AA substitution specific to these duplicates. We speculate that Fgfr1a had accumulated mutations in the ancestral lineage of scale-loss schizothoracine fishes before experiencing duplication events, which was further followed by the diversification of species. In silico mutation analysis predicted deleterious effects of the mutations while no disruptive molecular mechanism was detected. Collectively, our results highlight the important role of Fgfr1a gene in the adaptive evolution of schizothoracine fishes during their radiation in the Qinghai-Tibetan Plateau.
关键词	Adaptive Evolution Fgfr1a Scale Loss Schizothoracine
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1111/1749-4877.12178
关键词[WOS]	GROWTH-FACTOR-RECEPTOR ; SCALE DEVELOPMENT ; MAXIMUM-LIKELIHOOD ; EVO-DEVO ; EVOLUTION ; ZEBRAFISH ; DUPLICATION ; INFERENCE ; GENETICS ; MEDAKA
收录类别	SCI
语种	英语
项目资助者	Knowledge Innovation Project(KSCX2-EW-J-26) ; Youth Innovation Promotion Association Foundation of the Chinese Academy of Sciences
WOS研究方向	Zoology
WOS类目	Zoology
WOS记录号	WOS:000372860800001
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/5698
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, 23 Xinning Rd, Xining 810008, Qinghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Qinghai Univ Nationalities, Xining, Peoples R China 4.Qinghai Normal Univ, Xining, Peoples R China 5.Qinghai Univ, Dept Anim Sci, Agr & Anim Husb Coll, 97 Ningzhang Rd, Xining 810016, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Guo, Xinyi,Xie, Ling,Zhang, Xuze,et al. Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments[J]. INTEGRATIVE ZOOLOGY,2016,11(2):86-97.
APA	Guo, Xinyi.,Xie, Ling.,Zhang, Xuze.,Ji, Yinfa.,Chen, Juan.,...&Guo, Songchang.(2016).Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments.INTEGRATIVE ZOOLOGY,11(2),86-97.
MLA	Guo, Xinyi,et al."Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments".INTEGRATIVE ZOOLOGY 11.2(2016):86-97.