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Fluorescent turn-off/on bioassay for hemoglobin based on dual-emission carbon nanodots-graphene oxide system with multi-detection strategies
Qu, Fei1,2; Liu, Dongya1,2; You, Jinmao1,2,3
2016-05-19
Source PublicationANALYTICA CHIMICA ACTA
Volume921Pages:59-66
SubtypeArticle
AbstractAs two members of the carbon materials family, carbon nanodots (CNDs) and graphene oxide (GO) possess many excellent optical properties resulting in a wide range of applications. In this work, the fluorescence of resultant dual-emission carbon nanodots (DECNDs) could be quenched by GO. In the presence of hemoglobin (Hb), the fluorescence would recover resulting from two interactions: one was the direct stacking effect of Hb on GO; the other one was that Hb could cover the surfaces of DECNDs; both of them would prevent the fluorescence quenching of DECNDs by GO. In the light of this mechanism, a novel fluorescent turn-off/on method has been developed for the detection of Hb based on DECNDs-GO system. By virtue of the dual emissions of these CNDs, it is noteworthy that both a single emission and ratiometric of dual emissions can be used to establish linear relationships of Hb: 0.05 -300 nM (lambda em = 386 nm), 5-500 nM (lambda em = 530 nm), and 50-500 nM (I-530/I-410), with the corresponding limit of detection (LOD) as low as 20 pM, 2 nM and 20 nM, respectively. This present system is highly selective toward Hb over other proteins and this reliable method has been successfully applied for the detection of Hb in whole blood samples. (C) 2016 Elsevier B.V. All rights reserved.
KeywordCarbon Nanodots Dual Emissions Graphene Oxide Hemoglobin
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.aca.2016.03.048
WOS KeywordSENSITIVE DETECTION ; QUANTUM DOTS ; SENSOR ; NANOPARTICLES ; PROBES ; BLOOD ; CU2+ ; IONS
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China (Youth Fund Project)(21405093) ; Scientific Research Foundation of Qufu Normal University(BSQD20130117)
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000374643200006
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/5707
Collection中国科学院西北高原生物研究所
Affiliation1.Qufu Normal Univ, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China
2.Qufu Normal Univ, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China
3.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810001, Peoples R China
Recommended Citation
GB/T 7714
Qu, Fei,Liu, Dongya,You, Jinmao. Fluorescent turn-off/on bioassay for hemoglobin based on dual-emission carbon nanodots-graphene oxide system with multi-detection strategies[J]. ANALYTICA CHIMICA ACTA,2016,921:59-66.
APA Qu, Fei,Liu, Dongya,&You, Jinmao.(2016).Fluorescent turn-off/on bioassay for hemoglobin based on dual-emission carbon nanodots-graphene oxide system with multi-detection strategies.ANALYTICA CHIMICA ACTA,921,59-66.
MLA Qu, Fei,et al."Fluorescent turn-off/on bioassay for hemoglobin based on dual-emission carbon nanodots-graphene oxide system with multi-detection strategies".ANALYTICA CHIMICA ACTA 921(2016):59-66.
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