DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo

doi:10.1038/aps.2015.117

NWIPB OpenIR

	DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo
	Li, Meng-yuan 1,2,4; Lv, Yong-cong 3; Tong, Lin-jiang 2; Peng, Ting 2; Qu, Rong 2,4; Zhang, Tao 4,5; Sun, Yi-ming 2; Chen, Yi 2; Wei, Li-xin 1,4; Geng, Mei-yu 2; Duan, Wen-hu 3; Xie, Hua 2; Ding, Jian 2
	2016-03-01
发表期刊	ACTA PHARMACOLOGICA SINICA
卷号	37 期号:3 页码:398-407
文章类型	Article
摘要	Aim: Targeting the VEGF/VEGF receptor (VEGFR) pathway has proved to be an effective antiangiogenic approach for cancer treatment. Here, we identified 6-((2-((3-acetamidophenyl)amino)pyrimidin-4-yl)oxy)-N-phenyl-1-naphthamide (designated herein as DW10075) as a novel and highly selective inhibitor of VEGFRs.
关键词	Dw10075 Vegf/vegf Receptor Inhibitor Antitumor Angiogenesis U87-mg Human Glioblastoma
WOS标题词	Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
DOI	10.1038/aps.2015.117
关键词[WOS]	METASTATIC COLORECTAL-CANCER ; RENAL-CELL CARCINOMA ; ANGIOGENESIS INHIBITORS ; BEVACIZUMAB ; AXITINIB ; TARGETS ; KINASES ; POTENT
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81173080 ; National Key Technology R&D Program of the Ministry of Science and Technology of China(2012BAI27B02) ; Research Program of Qinghai province(2012-T-Y23) ; 81321092 ; 81374063)
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS记录号	WOS:000371426900012
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/5766
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Pharmacol & Safety Evaluat Key Lab Tibetan Med Qi, Xining 810008, Peoples R China 2.Chinese Acad Sci, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Dept Med Chem, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Shanghai Tech Univ, Shanghai 200120, Peoples R China
推荐引用方式 GB/T 7714	Li, Meng-yuan,Lv, Yong-cong,Tong, Lin-jiang,et al. DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo[J]. ACTA PHARMACOLOGICA SINICA,2016,37(3):398-407.
APA	Li, Meng-yuan.,Lv, Yong-cong.,Tong, Lin-jiang.,Peng, Ting.,Qu, Rong.,...&Ding, Jian.(2016).DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo.ACTA PHARMACOLOGICA SINICA,37(3),398-407.
MLA	Li, Meng-yuan,et al."DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo".ACTA PHARMACOLOGICA SINICA 37.3(2016):398-407.