NWIPB OpenIR
Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season
Liu, Ming1; Cao, Guangming1,4; Zhang, Yanming3; Qu, Jiapeng3; Li, Wei1; Wan, Xinrong2; Li, Yu-xia1; Zhang, Zhibin2; Wang, Yan-ling1; Gao, Fei1
2016-03-04
发表期刊SCIENTIFIC REPORTS
卷号6
文章类型Article
摘要Plateau pikas are seasonally breeding small herbivores that inhabit the meadow ecosystem of the Qinghai-Tibetan Plateau. Testis regression in plateau pikas begins in early June, and the male pikas are completely infertile, with a dramatically reduced testis size, in late July. In this study, a decreased germ cell number in the testes was first noted in early June. By late June, only Sertoli cells and a small number of spermatogonia remained. Interestingly, large gonocyte-like germ cells were observed in early July. In late July, the number of gonocyte-like cells per tubule increased significantly, and most of the Sertoli cell nuclei moved to and clustered in the center of the seminiferous tubules. The gonocyte-like germ cells and Sertoli cells began to express AP-2 gamma and anti-Mullerian hormone (AMH) proteins, which were detected in the germ cells and Sertoli cells of juvenile pikas but not in adult testes. Simultaneously, LC3 puncta dramatically increased in the seminiferous tubules of the pikas' testes during the nonbreeding season. Our study found that spermatogonia and Sertoli cells in non-breeding adult pikas morphologically resembled those in juvenile pikas and expressed specific markers, indicating that dedifferentiation- like transitions may occur during this process.
WOS标题词Science & Technology
DOI10.1038/srep22697
关键词[WOS]MESENCHYMAL STEM-CELLS ; OCHOTONA-CURZONIAE ; LIVER-REGENERATION ; TIBETAN PLATEAU ; MALE HAMSTERS ; PINEAL GLAND ; AUTOPHAGY ; MELATONIN ; DIFFERENTIATION ; TESTOSTERONE
收录类别SCI
语种英语
项目资助者National Key Basic Research Program of China(2013CB945001 ; National Natural Science Foundation of China(31171373 ; 2011CB944300 ; 31201715 ; 2007CB109100) ; 81525011)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000371524200001
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/5769
专题中国科学院西北高原生物研究所
作者单位1.Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Qinghai Tibetan Plateau Biol Adaptat & Ev, Xining 810008, Qinghai, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Liu, Ming,Cao, Guangming,Zhang, Yanming,et al. Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season[J]. SCIENTIFIC REPORTS,2016,6.
APA Liu, Ming.,Cao, Guangming.,Zhang, Yanming.,Qu, Jiapeng.,Li, Wei.,...&Gao, Fei.(2016).Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season.SCIENTIFIC REPORTS,6.
MLA Liu, Ming,et al."Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season".SCIENTIFIC REPORTS 6(2016).
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