Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals

NWIPB OpenIR

	Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals
	Liu, Zhen ; Wang, Wei ; Zhang, Tong-Zuo ; Li, Gong-Hua ; He, Kai ; Huang, Jing-Fei ; Jiang, Xue-Long ; Murphy, Robert W. ; Shi, Peng
	2014-02-07
发表期刊	PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES ; Liu, Z; Wang, W; Zhang, TZ; Li, GH; He, K; Huang, JF; Jiang, XL; Murphy, RW; Shi, P.Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals,PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES,2014,281(1776):
摘要	Hibernating mammals need to be insensitive to acid in order to cope with conditions of high CO2; however, the molecular basis of acid tolerance remains largely unknown. The African naked mole-rat (Heterocephalus glaber) and hibernating mammals share similar environments and physiological features. In the naked mole-rat, acid insensitivity has been shown to be conferred by the functional motif of the sodium ion channel Na(V)1.7. There is now an opportunity to evaluate acid insensitivity in other taxa. In this study, we tested for functional convergence of Na(V)1.7 in 71 species of mammals, including 22 species that hibernate. Our analyses revealed a functional convergence of amino acid sequences, which occurred at least six times independently in mammals that hibernate. Evolutionary analyses determined that the convergence results from both parallel and divergent evolution of residues in the functional motif. Our findings not only identify the functional molecules responsible for acid insensitivity in hibernating mammals, but also open new avenues to elucidate the molecular underpinnings of acid insensitivity in mammals.; Hibernating mammals need to be insensitive to acid in order to cope with conditions of high CO2; however, the molecular basis of acid tolerance remains largely unknown. The African naked mole-rat (Heterocephalus glaber) and hibernating mammals share similar environments and physiological features. In the naked mole-rat, acid insensitivity has been shown to be conferred by the functional motif of the sodium ion channel Na(V)1.7. There is now an opportunity to evaluate acid insensitivity in other taxa. In this study, we tested for functional convergence of Na(V)1.7 in 71 species of mammals, including 22 species that hibernate. Our analyses revealed a functional convergence of amino acid sequences, which occurred at least six times independently in mammals that hibernate. Evolutionary analyses determined that the convergence results from both parallel and divergent evolution of residues in the functional motif. Our findings not only identify the functional molecules responsible for acid insensitivity in hibernating mammals, but also open new avenues to elucidate the molecular underpinnings of acid insensitivity in mammals.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/57741
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Liu, Zhen,Wang, Wei,Zhang, Tong-Zuo,et al. Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals[J]. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Liu, Z; Wang, W; Zhang, TZ; Li, GH; He, K; Huang, JF; Jiang, XL; Murphy, RW; Shi, P.Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals,PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES,2014,281(1776):,2014.
APA	Liu, Zhen.,Wang, Wei.,Zhang, Tong-Zuo.,Li, Gong-Hua.,He, Kai.,...&Shi, Peng.(2014).Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals.PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES.
MLA	Liu, Zhen,et al."Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals".PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014).