Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos

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	Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos
	Dong, Wu ; Liu, Jie ; Wei, Lixin ; Yang Jingfeng ; Chernick, Melissa ; Hinton, David E.
	2016-08-23
发表期刊	PEERJ
摘要	This study examined developmental toxicity of different mercury compounds eluding some used in traditional medicines. Medaka (Oryzias latipes) embryos were exposed to 0.001-10 mu M concentrations of MeHg, HgCl2, alpha-HgS (Zhu Sha), and, beta-HgS (Zuotai) from stage 10 (6-7 hpf) to 10 days post fertilization (dpf). Of the forms of mercury in this study, the organic form (MeHg) proved the most toxic followed by inorganic mercury (HgCl2), both producing embryo developmental toxicity. Altered phenotypes included pericardial edema with elongated or tube heart, reduction of eye pigmentation, and failure of swim bladder inflation. Both alpha-HgS and, beta-HgS were less toxic than MeHg and HgCl2. Total RNA was extracted from survivors three days after exposure to MeHg (0.1 mu M), HgCl2 (1 mu M), alpha-HgS (10 mu M), or beta-HgS (10 mu M) to examine toxicity-related gene expression. MeHg and HgC12 markedly induced. metallothionein (MT) and heme oxygenase-1 (Ho-1), while alpha-HgS and beta-HgS faded to induce either gene. Chemical forms of mercury compounds proved to be a major determinant in their developmental toxicity.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/58338
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Dong, Wu,Liu, Jie,Wei, Lixin,et al. Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos[J]. PEERJ,2016.
APA	Dong, Wu,Liu, Jie,Wei, Lixin,Yang Jingfeng,Chernick, Melissa,&Hinton, David E..(2016).Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos.PEERJ.
MLA	Dong, Wu,et al."Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos".PEERJ (2016).