NWIPB OpenIR
A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens
Zhang, Shan-Shan ; Liao, Zhi-Xin ; Huang, Ri-Zhen ; Gong, Cheng-Cheng ; Ji, Lan-Ju ; Sun, Hong-Fa
2018
发表期刊NATURAL PRODUCT RESEARCH
摘要Chemical investigation of the ethanolic extracts of the dried leaves of Bergenia purpurascens led to the isolation and identification of a new aromatic glycoside, 1-O-ss-D-glucopyranosyl-2-methoxy-3-hydroxylphenylethene( 1), along with other 19 known compounds (2-20). The structure of compound 1 was determined by a detailed analysis using various analytical techniques, including 1D and 2D NMR. In vitro anti- proliferative activities of compound 1 on five human cancer cell lines were evaluated. The results showed that compound 1 possessed the most potent effects with the IC50 values of 14.36 +/- 1.04 mu M against T24 cells. The further bioactivity analysis showed that compound 1 induced apoptosis of T24 cells, and altered anti- and pro-apoptotic proteins, leading to mitochondrial dysfunction and activation of caspase-3 for causing cell apoptosis. The present investigation illustrated compound 1 might be used as a potential antitumour chemotherapy candidate.
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/59450
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Zhang, Shan-Shan,Liao, Zhi-Xin,Huang, Ri-Zhen,et al. A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens[J]. NATURAL PRODUCT RESEARCH,2018.
APA Zhang, Shan-Shan,Liao, Zhi-Xin,Huang, Ri-Zhen,Gong, Cheng-Cheng,Ji, Lan-Ju,&Sun, Hong-Fa.(2018).A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens.NATURAL PRODUCT RESEARCH.
MLA Zhang, Shan-Shan,et al."A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens".NATURAL PRODUCT RESEARCH (2018).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Shan-Shan]的文章
[Liao, Zhi-Xin]的文章
[Huang, Ri-Zhen]的文章
百度学术
百度学术中相似的文章
[Zhang, Shan-Shan]的文章
[Liao, Zhi-Xin]的文章
[Huang, Ri-Zhen]的文章
必应学术
必应学术中相似的文章
[Zhang, Shan-Shan]的文章
[Liao, Zhi-Xin]的文章
[Huang, Ri-Zhen]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。