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Molecularly imprinted polymer solid -phase microextraction coupled with ultra high performance liquid chromatography and tandem mass spectrometry for rapid analysis of pyrrolizidine alkaloids in herbal medicine
Luo, Zhimin; Chen, Guoning; Li, Xuan; Wang, Lu; Shu, Hua; Cui, Xia; Chang, Chun; Zeng, Aiguo; Fu, Qiang
2019
发表期刊JOURNAL OF SEPARATION SCIENCE
卷号42期号:21
摘要Pyrrolizidine alkaloids are the most widely distributed natural toxins, and pyrrolizidine alkaloid -containing herbal medicines are probably the most common poisonous plants affecting humans. We reported pyrrolizidine alkaloid -molecularly imprinted polymer solid -phase microextraction for the selective adsorption of toxic pyrrolizidine alkaloids from herbal medicine. A sulfonic compound, sodium allylsulfonate, was chosen as the functional monomer to interact with pyrrolizidine alkaloids through strong ionic interaction. To avoid template leakage and for the aim of cost saving, a relatively cheap dummy template was used for the fabrication of molecularly imprinted polymer -solid -phase microextraction fibers. The obtained fibers showed selective adsorption ability for four pyrrolizidine alkaloids, including europine, echimidine, lasiocarpine, and heliotrine. The extraction parameters, such as extraction time, extraction temperature, shaking speed, elution solvent and elution time, were optimized. Then ultra high performance liquid chromatography with mass spectrometry coupled with molecularly imprinted polymer-solid -phase microextraction method was developed for the fast and efficient analysis of four pyrrolizidine alkaloids from the model herbal plant Farfarae Flos. The established method was validated and exhibited satisfactory accuracy and precision. The present method provides an innovative and fast analytical strategy for the determination of trace toxic pyrrolizidine alkaloids in complicated samples.
关键词herbal medicine molecularly imprinted polymers pyrrolizidine alkaloids solid phase microextraction ultra high performance liquid chromatography
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/59681
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Luo, Zhimin,Chen, Guoning,Li, Xuan,et al. Molecularly imprinted polymer solid -phase microextraction coupled with ultra high performance liquid chromatography and tandem mass spectrometry for rapid analysis of pyrrolizidine alkaloids in herbal medicine[J]. JOURNAL OF SEPARATION SCIENCE,2019,42(21).
APA Luo, Zhimin.,Chen, Guoning.,Li, Xuan.,Wang, Lu.,Shu, Hua.,...&Fu, Qiang.(2019).Molecularly imprinted polymer solid -phase microextraction coupled with ultra high performance liquid chromatography and tandem mass spectrometry for rapid analysis of pyrrolizidine alkaloids in herbal medicine.JOURNAL OF SEPARATION SCIENCE,42(21).
MLA Luo, Zhimin,et al."Molecularly imprinted polymer solid -phase microextraction coupled with ultra high performance liquid chromatography and tandem mass spectrometry for rapid analysis of pyrrolizidine alkaloids in herbal medicine".JOURNAL OF SEPARATION SCIENCE 42.21(2019).
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