Associations of ORMDL1 gene copy number variations with growth traits in four Chinese sheep breeds

NWIPB OpenIR

	Associations of ORMDL1 gene copy number variations with growth traits in four Chinese sheep breeds
	Wang, Xiaogang; Cao, Xiukai; Wen, Yifan; Ma, Yilei; Elnour, Ibrahim Elsaeid; Huang, Yongzhen; Lan, Xianyong; Chaogetu, Buren; Hu, Linyong; Chen, Hong
	2019
发表期刊	ARCHIVES ANIMAL BREEDING
卷号	62 期号:2
摘要	Copy number variations (CNVs) are gains and losses of genomic sequence of more than 50 bp between two individuals of a species. Also, CNV is considered to be one of the main elements affecting the phenotypic diversity and evolutionary adaptation of animals. ORMDL sphingolipid biosynthesis regulator 1 (ORMDL1) is a protein-coding gene associated with diseases and development. In our study, the polymorphism of ORMDL1 gene copy numbers in four Chinese sheep breeds (abbreviated CK, HU, STH, and LTH) was detected. In addition, we analyzed the transcriptional expression level of ORMDL1 gene in different tissues of sheep and examined the association of ORMDL1 CNV with growth traits. The statistical analysis revealed that ORMDL1 CNV was remarkably correlated with body height, heart girth, and circumference of cannon bone in HU sheep (P < 0.05), and there are significant effects on body weight, body height, body length, chest depth, and height of hip cross in STH sheep (P < 0.05). In conclusion, our results provide a basis for the relationship between CNV of ORMDL1 gene and sheep growth traits, suggesting that ORMDL1 CNV may be considered a promising marker for the molecular breeding of Chinese sheep.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/59685
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Wang, Xiaogang,Cao, Xiukai,Wen, Yifan,et al. Associations of ORMDL1 gene copy number variations with growth traits in four Chinese sheep breeds[J]. ARCHIVES ANIMAL BREEDING,2019,62(2).
APA	Wang, Xiaogang.,Cao, Xiukai.,Wen, Yifan.,Ma, Yilei.,Elnour, Ibrahim Elsaeid.,...&Chen, Hong.(2019).Associations of ORMDL1 gene copy number variations with growth traits in four Chinese sheep breeds.ARCHIVES ANIMAL BREEDING,62(2).
MLA	Wang, Xiaogang,et al."Associations of ORMDL1 gene copy number variations with growth traits in four Chinese sheep breeds".ARCHIVES ANIMAL BREEDING 62.2(2019).