NWIPB OpenIR
Emissions of terbium metal-organic frameworks modulated by dispersive/agglomerated gold nanoparticles for the construction of prostate-specific antigen biosensor
Qu, Fei; Ding, Yanru; Lv, Xiaoxia; Xia, Lian; You, Jinmao; Han, Wenli
2019
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume411Issue:17
AbstractHerein, a universal and multifunctional fluorescence sensor platform is designed by the interaction of aggregation/dispersion gold nanoparticles (AuNPs) with Tb-metal-organic frameworks (Tb-MOFs). It is found that the dispersed AuNPs rather than the aggregated ones can quench effectively the fluorescence of Tb-MOFs, and the quenching process presumably involves the mechanism of inner filter effect (IFE), dynamic quenching effect (DQE), and fluorescence resonance energy transfer (FRET). The different affinities of aptamer and aptamer-target complex toward AuNPs are employed to modulate the fluorescence signal change of Tb-MOFs. As the proof of concept, prostate-specific antigen (PSA), an efficient tumor indicator for prostate cancer, is selected as the target. At first, the PSA aptamer can protect AuNPs against salt-induced aggregation, leading to the fluorescence of Tb-MOFs quenching. Subsequently, upon PSA introduction, the rigid aptamer-PSA complex is formed and cannot stabilize AuNPs in high salt conditions, so the AuNPs aggregate significantly and the fluorescence of Tb-MOFs is restored. The linear range of PSA is achieved from 1 to 100ng/mL with a detection limit of 0.36ng/mL. Finally, this method has been validated to be sensitive and specific for PSA in human urine samples.
KeywordFluorescence Metal-organic frameworks Gold nanoparticles Prostate-specific antigen Aptamer
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/59758
Collection中国科学院西北高原生物研究所
Recommended Citation
GB/T 7714
Qu, Fei,Ding, Yanru,Lv, Xiaoxia,et al. Emissions of terbium metal-organic frameworks modulated by dispersive/agglomerated gold nanoparticles for the construction of prostate-specific antigen biosensor[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2019,411(17).
APA Qu, Fei,Ding, Yanru,Lv, Xiaoxia,Xia, Lian,You, Jinmao,&Han, Wenli.(2019).Emissions of terbium metal-organic frameworks modulated by dispersive/agglomerated gold nanoparticles for the construction of prostate-specific antigen biosensor.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,411(17).
MLA Qu, Fei,et al."Emissions of terbium metal-organic frameworks modulated by dispersive/agglomerated gold nanoparticles for the construction of prostate-specific antigen biosensor".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 411.17(2019).
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