Effects of Yak skin gelatin on platelet activation

NWIPB OpenIR

	Effects of Yak skin gelatin on platelet activation
	Chen, Qi; Yang, Hongxia; Li, Yan; Wang, Xiaoxi; Wei, Lixin; Du, Yuzhi
	2019
Source Publication	FOOD & FUNCTION
Volume	10 Issue:6
Abstract	Studies have shown that gelatin is not only a good hemostatic material, but also a food additive with potentially broad use. Yak skin gelatin is a new gelatin resource, but its oral coagulant effects have not been studied. Given the central role of platelets in hemostasis, in this study we examined the pharmacodynamical differences between different molecular Yak skin gelatins on platelet activation. The hemostatic effects of Yak skin gelatins with different molecular weight distributions were evaluated for bleeding time (BT), clotting time (CT), and platelet activity by measuring the contents of P-selectin, platelet membrane glycoprotein Ia/IIa (GP Ia/IIa), platelet membrane glycoprotein IIb/IIIa (GP IIb/IIIa), and platelet membrane glycoprotein IV (GP IV). Intragastric administration of Yak skin gelatin resulted in a significant reduction in CT and BT, and an increase in the contents of P-selectin, GP Ia/IIa, GP IIb/IIIa, and GP IV in all groups in comparison with the control group. The strongest activation of platelets by Yak skin gelatin was observed with size between 0.1 mu m and 0.22 mu m, and activation may have been in response to improving GP IIb/IIIa and GP IV levels. When measuring the levels of an established indicator of platelet activation, platelet activation-dependent granule membrane protein (CD62P), its promotion was observed for all molecular weight ranges of Yak skin gelatins. In brief, Yak skin gelatin has hemostatic effects, and Yak skin gelatin fractions between 0.1 mu m and 0.22 mu m are the primary effectors of hemostasis via promoting platelet membrane glycoprotein activities and strengthening platelet function.
Document Type	期刊论文
Identifier	http://210.75.249.4/handle/363003/59771
Collection	中国科学院西北高原生物研究所
Recommended Citation GB/T 7714	Chen, Qi,Yang, Hongxia,Li, Yan,et al. Effects of Yak skin gelatin on platelet activation[J]. FOOD & FUNCTION,2019,10(6).
APA	Chen, Qi,Yang, Hongxia,Li, Yan,Wang, Xiaoxi,Wei, Lixin,&Du, Yuzhi.(2019).Effects of Yak skin gelatin on platelet activation.FOOD & FUNCTION,10(6).
MLA	Chen, Qi,et al."Effects of Yak skin gelatin on platelet activation".FOOD & FUNCTION 10.6(2019).

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