Synthesis of novel nanosized fluorinated carbon fiber with high NIR absorption and its application in cancer chemo-photothermal therapy

NWIPB OpenIR

	Synthesis of novel nanosized fluorinated carbon fiber with high NIR absorption and its application in cancer chemo-photothermal therapy
	Zhang, Lei; Wang, Mengzhen; Kong, Fei; Li, Shuohan; Dai, Gangyan; Gong, Peiwei; Liu, Zhe; You, Jinmao
	2019
发表期刊	MATERIALS LETTERS
卷号	244
摘要	Although fluorinated carbon fiber (FC) inherits many excellent properties of carbon materials, and holds great promise in many fields. However, chemical modification and application of FC in biomedicine have been rarely studied, mostly ascribed to large-sized needle-like structure, and inert C-F bonds with strong hydrophobicity. Herein, fluorinated carbon fiber oxide (FCO) enriched with oxygen groups with an average size of 90 nm is prepared, and this then allows us for the first time to modify FCO with biomolecule of hyaluronic acid, rendering FCO special targeting and good dispersibility in various media. Effective control over structure and surface makes FCO exhibit negligible toxicity and possess high near infrared absorption for photothermal therapy (PTT). Moreover, FCO also has high drug load capacity (1.05 mg/mg), and cell experiments confirm better therapeutic effect of the nanocarrier than single PTT or chemotherapy, making it practically valuable for cancer chemo-photothermal therapy. (C) 2019 Elsevier B.V. All rights reserved.
关键词	Fluorinated carbon fiber Photothermal performance Carbon materials Cell experiment
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/59785
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhang, Lei,Wang, Mengzhen,Kong, Fei,et al. Synthesis of novel nanosized fluorinated carbon fiber with high NIR absorption and its application in cancer chemo-photothermal therapy[J]. MATERIALS LETTERS,2019,244.
APA	Zhang, Lei.,Wang, Mengzhen.,Kong, Fei.,Li, Shuohan.,Dai, Gangyan.,...&You, Jinmao.(2019).Synthesis of novel nanosized fluorinated carbon fiber with high NIR absorption and its application in cancer chemo-photothermal therapy.MATERIALS LETTERS,244.
MLA	Zhang, Lei,et al."Synthesis of novel nanosized fluorinated carbon fiber with high NIR absorption and its application in cancer chemo-photothermal therapy".MATERIALS LETTERS 244(2019).