NWIPB OpenIR
Traditional Tibetan medicine Anzhijinhua San attenuates ovalbumin-induced diarrhea by regulating the serotonin signaling system in mice
Xia, Zhenjiang; Zhang, Yifan; Li, Cen; Xu, Yan; Dong, Jinjin; Wang, Lulu; He, Qiangqiang; Zou, Xiaoyan; Wu, Huali; Han, Jichun; Cai, Minxuan; Du, Yuzhi; Wei, Lixin; Shang, Jing
2019
发表期刊JOURNAL OF ETHNOPHARMACOLOGY
卷号236
摘要Ethnopharmacological relevance: Tibetan medicine has been practiced for 3800 years. Anzhijinhua San (AZJHS), which is a traditional Tibetan medicine, has been effective in the treatment of indigestion, anorexia and cold diarrhea. However, the effects of AZJHS on allergic diarrhea have not been reported. Aim of the study: The aim of the present study was to elucidate the effect of AZJHS on experimental ovalbumin-induced diarrhea and elucidate its possible mechanism. Materials and methods: Female BALB/c mice were sensitized by intraperitoneal injection with 50 mu g ovalbumin (OVA) and 1 mg alum in saline twice during a 2-week period. From day 28, mice were orally challenged with OVA (50 mg) every other day for a total of ten times. AZJHS (46.8 and 468.0 mg/kg) was orally administered every other day from day 0-46. Food allergy symptoms were evaluated. OVA- specific IgE, 5-HT and its metabolites in serum were determined. Immunohistochemical and histopathology were performed in gastrointestinal tract tissues. 5-HT-relatedgene expression was assayed in the colon. Results: Severe symptoms of allergic diarrhea were observed in the model group (diarrhea, anaphylactic response, and rectal temperature). AZJHS (46.8 and 468.0 mg/kg) significantly reduced mouse diarrhea and significantly prevented the increases in OVA-specific IgE levels (P < 0.05), which challenge with OVA. AZJHS (46.8 and 468.0 mg/kg) significantly prevented the increases in 5-HT-positive cells. The nuclei of EC cells in the AZJHS (46.8 and 468.0 mg/kg) group increased in size and the secretory granules were fewer in number compared with those in the model group. AZJHS (46.8 and 468.0 mg/kg) significantly increased the relative fold changes of 5-HTP and 5-HT compared with the model group. The mRNA expression of the serotonin transporter (Sert) and serotonin receptor 3A (Htr3a) was significantly decreased after the 10th challenge with OVA, and AZJHS (46.8 and 468.0 mg/kg) significantly increased these levels. Conclusions: We demonstrated that the administration of AZJHS attenuated OVA-induced diarrhea by regulating the serotonin pathway. These results indicated that AZJHS may be a potential candidate as an anti-allergic diarrhea agent.
关键词Allergic diarrhea Ovalbumin Tibetan medicine Anzhijinhua San Serotonin
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/59788
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Xia, Zhenjiang,Zhang, Yifan,Li, Cen,et al. Traditional Tibetan medicine Anzhijinhua San attenuates ovalbumin-induced diarrhea by regulating the serotonin signaling system in mice[J]. JOURNAL OF ETHNOPHARMACOLOGY,2019,236.
APA Xia, Zhenjiang.,Zhang, Yifan.,Li, Cen.,Xu, Yan.,Dong, Jinjin.,...&Shang, Jing.(2019).Traditional Tibetan medicine Anzhijinhua San attenuates ovalbumin-induced diarrhea by regulating the serotonin signaling system in mice.JOURNAL OF ETHNOPHARMACOLOGY,236.
MLA Xia, Zhenjiang,et al."Traditional Tibetan medicine Anzhijinhua San attenuates ovalbumin-induced diarrhea by regulating the serotonin signaling system in mice".JOURNAL OF ETHNOPHARMACOLOGY 236(2019).
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