The highly efficient elimination of intracellular bacteria via a metal organic framework (MOF)-based three-in-one delivery system

NWIPB OpenIR

	The highly efficient elimination of intracellular bacteria via a metal organic framework (MOF)-based three-in-one delivery system
	Zhang, Xu; Liu, Lizhi; Huang, Lunjie; Zhang, Wentao; Wang, Rong; Yue, Tianli; Sun, Jing; Li, Guoliang; Wang, Jianlong
	2019
发表期刊	NANOSCALE
卷号	11 期号:19
摘要	Numerous infectious diseases that cause clinical failures and relapses after antibiotic therapy have been confirmed to be induced by pathogenic intracellular bacteria. The existing therapeutic strategies fail to eliminate intracellular bacteria mainly due to a guard reservoir provided by the cell membrane, which can deactivate antibiotics. Herein, we have reported the design of a pH-responsive metal organic framework (MOF)/antibiotic synergistic system for the targeted highly efficient elimination of intracellular bacteria. The obtained tetracycline (Tet)@ZIF-8@ hyaluronic acid (HA) system (abbreviated to TZH) can be taken up by cells owing to the presence of CD44 receptors on the cell surface via an HA-mediated pathway. Zinc ions and antibiotics, released from TZH under acidic conditions caused by bacteria, have a synergistic antibacterial effect both in vitro and in vivo. The clearance rate of TZH to the intracellular bacteria reached over 98% within the limits of biotoxicity, which indicated that this delivery system can pass the cell membrane barriers and restore the efficacy of endangered antibiotics. This synergistic strategy shows potential in optimizing the efficacy-dosage correlation of antibiotics for related infection treatments and constructing versatile controlled release delivery systems for a broad range of applications.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/59789
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhang, Xu,Liu, Lizhi,Huang, Lunjie,et al. The highly efficient elimination of intracellular bacteria via a metal organic framework (MOF)-based three-in-one delivery system[J]. NANOSCALE,2019,11(19).
APA	Zhang, Xu.,Liu, Lizhi.,Huang, Lunjie.,Zhang, Wentao.,Wang, Rong.,...&Wang, Jianlong.(2019).The highly efficient elimination of intracellular bacteria via a metal organic framework (MOF)-based three-in-one delivery system.NANOSCALE,11(19).
MLA	Zhang, Xu,et al."The highly efficient elimination of intracellular bacteria via a metal organic framework (MOF)-based three-in-one delivery system".NANOSCALE 11.19(2019).