NWIPB OpenIR
Copy number variation (CNV) in the IGF1R gene across four cattle breeds and its association with economic traits
Ma, Yi-Lei; Wen, Yi-Fan; Cao, Xiu-Kai; Cheng, Jie; Huang, Yong-Zhen; Ma, Yun; Hu, Lin-Yong; Lei, Chu-Zhao; Qi, Xing-Lei; Cao, Hui; Chen, Hong
2019
发表期刊ARCHIVES ANIMAL BREEDING
卷号62期号:1
摘要The insulin-like growth factor 1 receptor (IGF1R) plays a vital role in immunomodulation and muscle and bone growth. The copy number variation (CNV) is believed to the reason for many complex phenotypic variations. In this paper, we statistically analyzed the copy number and the expression profiling in different tissue types of the IGF1R gene using the 422 samples from four Chinese beef cattle breeds, and the mRNA of IGF1R was widely expressed in nine tissue types of adult cattle (heart, liver, kidney, muscle, fat, stomach, spleen, lung and testis). Results of CNV and growth traits indicated that the IGF1R CNV was significantly associated with body weight and body height of Jinnan (JN) cattle and was significantly associated with body height and hucklebone width of Qinchuan (QC) cattle, making IGF1R CNV a promising molecular marker to improve meat production in beef cattle breeding. Bioinformatics predictions show that the CNV region is highly similar to the human genome, and there are a large number of transcription factors, DNase I hypersensitive sites, and high levels of histone acetylation, suggesting that this region may play a role in transcriptional regulation, providing directions for further study of the role of bovine CNV and economic traits.
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/59817
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Ma, Yi-Lei,Wen, Yi-Fan,Cao, Xiu-Kai,et al. Copy number variation (CNV) in the IGF1R gene across four cattle breeds and its association with economic traits[J]. ARCHIVES ANIMAL BREEDING,2019,62(1).
APA Ma, Yi-Lei.,Wen, Yi-Fan.,Cao, Xiu-Kai.,Cheng, Jie.,Huang, Yong-Zhen.,...&Chen, Hong.(2019).Copy number variation (CNV) in the IGF1R gene across four cattle breeds and its association with economic traits.ARCHIVES ANIMAL BREEDING,62(1).
MLA Ma, Yi-Lei,et al."Copy number variation (CNV) in the IGF1R gene across four cattle breeds and its association with economic traits".ARCHIVES ANIMAL BREEDING 62.1(2019).
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