Anthocyanins from Lycium ruthenicum Murr. Ameliorated D-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats

NWIPB OpenIR

	Anthocyanins from Lycium ruthenicum Murr. Ameliorated D-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats
	Chen, Shasha; Zhou, Haonan; Zhang, Gong; Meng, Jing; Deng, Kai; Zhou, Wu; Wang, Honglun; Wang, Zhenhua; Hu, Na; Suo, Yourui
	2019
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷号	67 期号:11
摘要	Lycium ruthenicum Murr. (LR) is a perennial shrub commonly used as a nutritional food and medicine. Herein, we identified 12 anthocyanins from LR, with petunidin derivatives constituting approximately 97% of the total anthocyanin content. Furthermore, the potential mechanism of anthocyanins exerting neuroprotective effects in D-galactose (D-gal)-treated rats was explored. Behavioral results showed that anthocyanins relieved D-gal-induced memory disorder. Additionally, anthocyanins reduced receptor for advanced glycation end products (RAGE) and suppressed oxidative stress caused by D-gal. Anthocyanins suppressed microgliosis and astrocytosis and reduced the overexpression of nuclear factor kappa B (NF-kappa B), interleukin-1-beta (IL-1 beta)cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha). Moreover, anthocyanins lowered C-jun N-terminal kinase (p-JNK), caspase-3 levels, and the B-cell lymphoma 2-associated X protein/B-cell lymphoma 2 (Bax/Bcl2) ratio. Thus, anthocyanins from LR attenuated memory disfunction, neuroinflammation, and neurodegeneration caused by D-gal, possibly through the RAGE/NF-kappa B/JNK pathway, representing a promising, safe candidate for prevention and therapy of neurodegenerative diseases.
关键词	Lycium ruthenicum Murr anthocyanins oxidative stress memory impairment neuroinflammation neurodegeneration
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/59831
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Chen, Shasha,Zhou, Haonan,Zhang, Gong,et al. Anthocyanins from Lycium ruthenicum Murr. Ameliorated D-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(11).
APA	Chen, Shasha.,Zhou, Haonan.,Zhang, Gong.,Meng, Jing.,Deng, Kai.,...&Suo, Yourui.(2019).Anthocyanins from Lycium ruthenicum Murr. Ameliorated D-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(11).
MLA	Chen, Shasha,et al."Anthocyanins from Lycium ruthenicum Murr. Ameliorated D-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.11(2019).