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A concise synthesis and biological study of evodiamine and its analogues
Deng, Jie-Dan; Lei, Shuai; Jiang, Yi; Zhang, Hong-Hua; Hu, Xiao-Ling; Wen, Huai-Xiu; Tan, Wen; Wang, Zhen
2019
Source PublicationCHEMICAL COMMUNICATIONS
Volume55Issue:21
AbstractEfficient access to evodiamine and its analogues is presented via Lewis acid catalysis. In this reaction, three chemical bonds and two heterocyclic-fused rings are constructed in one step. The reaction shows good functional group tolerance and atom economy, and various heteroatom-containing evodiamine analogues are obtained in moderate to excellent yields even on a gram scale. An anti-tumor study in vitro demonstrates compound 2b possesses potent efficacy against hepatoma cell line (IC50 = 5.7 mu M).
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/59833
Collection中国科学院西北高原生物研究所
Recommended Citation
GB/T 7714
Deng, Jie-Dan,Lei, Shuai,Jiang, Yi,et al. A concise synthesis and biological study of evodiamine and its analogues[J]. CHEMICAL COMMUNICATIONS,2019,55(21).
APA Deng, Jie-Dan.,Lei, Shuai.,Jiang, Yi.,Zhang, Hong-Hua.,Hu, Xiao-Ling.,...&Wang, Zhen.(2019).A concise synthesis and biological study of evodiamine and its analogues.CHEMICAL COMMUNICATIONS,55(21).
MLA Deng, Jie-Dan,et al."A concise synthesis and biological study of evodiamine and its analogues".CHEMICAL COMMUNICATIONS 55.21(2019).
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