Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development | |
Xu, Yan; Han, Jichun; Dong, Jinjin; Fan, Xiangcheng; Cai, Yuanyuan; Li, Jing; Wang, Tao; Zhou, Jia; Shang, Jing | |
2019 | |
发表期刊 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
卷号 | 20期号:5 |
摘要 | As metabolomics is widely used in the study of disease mechanisms, an increasing number of studies have found that metabolites play an important role in the occurrence of diseases. The aim of this study is to investigate the effects and mechanisms of quercetin in high-fat-sucrose diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) development using nontargeted metabolomics. A rat model of NAFLD was established by feeding with an HFD for 30 and 50 days. The results indicated quercetin exhibited hepatoprotective activity in 30-day HFD-induced NAFLD rats by regulating fatty acid related metabolites (adrenic acid, etc.), inflammation-related metabolites (arachidonic acid, etc.), oxidative stress-related metabolites (2-hydroxybutyric acid) and other differential metabolites (citric acid, etc.). However, quercetin did not improve NAFLD in the 50-day HFD; perhaps quercetin was unable to reverse the inflammation induced by a long-term high-fat diet. These data indicate that dietary quercetin may be beneficial to NAFLD in early stages. Furthermore, combining metabolomics and experimental approaches opens avenues to study the effects and mechanisms of drugs for complex diseases. |
关键词 | nonalcoholic fatty liver disease high fat-sucrose diet metabolomics HPLC-QTOF-MS quercetin |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/59840 |
专题 | 中国科学院西北高原生物研究所 |
推荐引用方式 GB/T 7714 | Xu, Yan,Han, Jichun,Dong, Jinjin,et al. Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2019,20(5). |
APA | Xu, Yan.,Han, Jichun.,Dong, Jinjin.,Fan, Xiangcheng.,Cai, Yuanyuan.,...&Shang, Jing.(2019).Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,20(5). |
MLA | Xu, Yan,et al."Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20.5(2019). |
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