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Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development
Xu, Yan; Han, Jichun; Dong, Jinjin; Fan, Xiangcheng; Cai, Yuanyuan; Li, Jing; Wang, Tao; Zhou, Jia; Shang, Jing
2019
发表期刊INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号20期号:5
摘要As metabolomics is widely used in the study of disease mechanisms, an increasing number of studies have found that metabolites play an important role in the occurrence of diseases. The aim of this study is to investigate the effects and mechanisms of quercetin in high-fat-sucrose diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) development using nontargeted metabolomics. A rat model of NAFLD was established by feeding with an HFD for 30 and 50 days. The results indicated quercetin exhibited hepatoprotective activity in 30-day HFD-induced NAFLD rats by regulating fatty acid related metabolites (adrenic acid, etc.), inflammation-related metabolites (arachidonic acid, etc.), oxidative stress-related metabolites (2-hydroxybutyric acid) and other differential metabolites (citric acid, etc.). However, quercetin did not improve NAFLD in the 50-day HFD; perhaps quercetin was unable to reverse the inflammation induced by a long-term high-fat diet. These data indicate that dietary quercetin may be beneficial to NAFLD in early stages. Furthermore, combining metabolomics and experimental approaches opens avenues to study the effects and mechanisms of drugs for complex diseases.
关键词nonalcoholic fatty liver disease high fat-sucrose diet metabolomics HPLC-QTOF-MS quercetin
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/59840
专题中国科学院西北高原生物研究所
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GB/T 7714
Xu, Yan,Han, Jichun,Dong, Jinjin,et al. Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2019,20(5).
APA Xu, Yan.,Han, Jichun.,Dong, Jinjin.,Fan, Xiangcheng.,Cai, Yuanyuan.,...&Shang, Jing.(2019).Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,20(5).
MLA Xu, Yan,et al."Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20.5(2019).
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