NWIPB OpenIR
Design of a multifunctional biotinylated copper complex for visualization and quantification of cancer hypoxia levels
Li, Zan; Zhu, Zhenzhu; Sun, Zhiwei; Ding, Jie; You, Jinmao
2019
发表期刊SENSORS AND ACTUATORS B-CHEMICAL
卷号282
摘要Hypoxia, a typical hallmark of solid tumors, is associated closely with tumor progression and therapy resistance. Optical imaging has served as a powerful approach to study hypoxia in cancer cells. However, the noninvasive quantification of hypoxia levels in cancer cells is currently lacking. Herein, we report the design, synthesis, and biological evaluation of compound M, a novel fluorescence chemosensor to quantify hypoxia levels that relies on hypoxia-activated bioreduction. The remarkable selectivity and spectrum stability of compound M enabled us to visualize hypoxia and quantify the degree of hypoxia by high-throughput flow cytometry analysis in oxygen-deprived cancer cells. Furthermore, the HIF-1 alpha level suppression in cancer cells was achieved by compound M. With the realization of hypoxia levels quantification in a cobalt-treated hypoxia model, we envision that multifunctional compound M will find widespread applications in the study of physiological and pathological processes associated with hypoxia.
关键词Cancer Copper complex Fluorescence visualization Quantification Hypoxia levels HIF-1 alpha suppression
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/59850
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Li, Zan,Zhu, Zhenzhu,Sun, Zhiwei,et al. Design of a multifunctional biotinylated copper complex for visualization and quantification of cancer hypoxia levels[J]. SENSORS AND ACTUATORS B-CHEMICAL,2019,282.
APA Li, Zan,Zhu, Zhenzhu,Sun, Zhiwei,Ding, Jie,&You, Jinmao.(2019).Design of a multifunctional biotinylated copper complex for visualization and quantification of cancer hypoxia levels.SENSORS AND ACTUATORS B-CHEMICAL,282.
MLA Li, Zan,et al."Design of a multifunctional biotinylated copper complex for visualization and quantification of cancer hypoxia levels".SENSORS AND ACTUATORS B-CHEMICAL 282(2019).
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