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Anti-inflammatory activity of compounds isolated from Swertia mussotii
Yuan Xiang; Wang Haixia; Liu Zenggen; Tao Yanduo
2019
发表期刊NATURAL PRODUCT RESEARCH
卷号33期号:4
摘要Six compounds were isolated from an ethanol extract of Swertia mussotii and identified as 2-phenylethyl-beta-D-glucoside (1), amaroswerin (2), 1,3,7,8-tetrahydroxyxanthone (3), swertiamarine (4), 1,3,8-trihydroxy-5-methoxyxanthone (5) and methylswertianin (6). Compounds 1, 2 and 6 were isolated from S. mussotii for the first time. The anti-inflammatory activities of the compounds were evaluated by determining their effect on the production of NO by LPS-stimulated RAW264.7 cells. Amaroswerin was the most potent inhibitor of NO release, with an IC50 value of 5.42 mu g/mL. Treatment with amaroswerin inhibited expression of iNOS at both protein and mRNA levels. Amaroswerin also dose-dependently suppressed production of TNF-alpha, IL-6 and IL-1 beta and reduced expression of mRNA for these LPS-stimulated pro-inflammatory mediators. Amaroswerin thus inhibits the expression of iNOS, TNF-alpha, IL-6 and IL-1 beta by downregulating transcription in LPS-induced RAW264.7 macrophage cells, indicating that amaroswerin may be a valuable therapeutic agent for the treatment of inflammatory diseases. [GRAPHICS] .
关键词Swertia mussotii anti-inflammatory RAW264 7 cells pro-inflammatory mediators
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/59855
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Yuan Xiang,Wang Haixia,Liu Zenggen,et al. Anti-inflammatory activity of compounds isolated from Swertia mussotii[J]. NATURAL PRODUCT RESEARCH,2019,33(4).
APA Yuan Xiang,Wang Haixia,Liu Zenggen,&Tao Yanduo.(2019).Anti-inflammatory activity of compounds isolated from Swertia mussotii.NATURAL PRODUCT RESEARCH,33(4).
MLA Yuan Xiang,et al."Anti-inflammatory activity of compounds isolated from Swertia mussotii".NATURAL PRODUCT RESEARCH 33.4(2019).
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