NWIPB OpenIR
A ratiometric detection of heparin with high sensitivity based on aggregation-enhanced emission of gold nanoclusters triggered by silicon nanoparticles
Qu, Fei; Xia, Wenle; Xia, Lian; You, Jinmao; Han, Wenli
2019
发表期刊TALANTA
卷号193
摘要Heparin (Hep) is a widely applied anticoagulant and the quantification of heparin concentration is pivotal for clinical use. In this work, silicon nanoparticles (SiNPs) modified by the amino groups and glutathione-capped gold nanoclusters (GSH-AuNCs) are able to self-assemble into spherical particle structures via the electrostatic interaction, resulting in the aggregation-enhanced emission (AEE) of GSH-AuNCs. However, Hep, a highly sulfated glycosaminoglycan with much more negative charges, can bind with the SiNPs and inhibit the aggregation. As a result, it causes the AEE quenching of GSH-AuNCs at 570 nm but the SiNPs keep their own blue fluorescence at 450 nm. Thus, the SiNPs can act as an internal reference and the GSH-AuNCs are used as a signal probe in this process. The ratiometric fluorescent signal (I-570/I-450) change of the nanohybrid probe is positively correlated with Hep concentrations in the range from 6.44 ng/mL to 96.6 ng/mL with the detection limit of 3.29 ng/mL. As expected, this strategy shows good sensitivity and selectivity, and it is also successfully applied to detect Hep in Hep sodium injection and human serum samples with good recoveries.
关键词Self-assembly Aggregation-enhanced emission Ratiometric fluorescence Silicon nanoparticles Gold nanoclusters Heparin
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/59871
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Qu, Fei,Xia, Wenle,Xia, Lian,et al. A ratiometric detection of heparin with high sensitivity based on aggregation-enhanced emission of gold nanoclusters triggered by silicon nanoparticles[J]. TALANTA,2019,193.
APA Qu, Fei,Xia, Wenle,Xia, Lian,You, Jinmao,&Han, Wenli.(2019).A ratiometric detection of heparin with high sensitivity based on aggregation-enhanced emission of gold nanoclusters triggered by silicon nanoparticles.TALANTA,193.
MLA Qu, Fei,et al."A ratiometric detection of heparin with high sensitivity based on aggregation-enhanced emission of gold nanoclusters triggered by silicon nanoparticles".TALANTA 193(2019).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Qu, Fei]的文章
[Xia, Wenle]的文章
[Xia, Lian]的文章
百度学术
百度学术中相似的文章
[Qu, Fei]的文章
[Xia, Wenle]的文章
[Xia, Lian]的文章
必应学术
必应学术中相似的文章
[Qu, Fei]的文章
[Xia, Wenle]的文章
[Xia, Lian]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。