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Effects on Expression of Hepatic Phase-1 and Phase-2 Metabolism and Transporter Genes by Swertia mussotii Extract, A Hepatoprotective Herb from Tibetan Traditional Medicine
Yang, Hongxia; Xiao, Yuancan; Li, Cen; Gao, Tingting; Wei, Lixin; Du, Yuzhi
2019
发表期刊INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGY
卷号21期号:5
摘要To study the effects of Swertia mussotii extract on the expression of drug processing genes, including Phase-1 (cytochrome P450 enzyme genes), Phase-2 (glucuronidation and sulfation genes) and Phase-3 (drug transporters) in mouse liver. Mice were orally administered S. mussotii extract at the dose of 0.1, 0.3, 1.0, 3.0 g/kg for consecutive eight days. Blood and livers were collected at the time of 24 h after dosing. RT-PCR was used to analysis of genes of interest. S. mussotii extract ingestion induced Cyp2b10 and inhibited Cyp3a11 at all doses, while increased the expressions of Cyp2e1 at the dose of 0.1 and 0.3 g/kg and decreased the expression gradually at the dose of 1.0 and 3.0 g/kg. For phase-2 enzyme genes, S. mussotii extract increased sulfotransferase (Sult1a1), heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (Nqo1), but had no effects on glucuronyltransferases (Ugt1a1 and Ugt1a6) and sulfotransferase (Sult1b1). It is very interesting that S. mussotii extract inhibited mRNA levels in the hepatic organic anion-transporting polypetides (Oatp1a1 and Oatp2b1) and induced multidrug resistance-associated proteins, such as Mrp1 and Mrp4 were especially induced at 3.0 mg/kg. The metabolism of S. mussotii extract includes the induction of cytochrome P450 enzyme genes, hepatic transporters and phase-2 enzyme genes. The S. mussotii extracts influenced all types of metabolic drug processing genes and therefore could play a role in producing herbdrug interactions. (C) 2019 Friends Science Publishers
关键词Tibetan traditional medicine Swertia mussotii Cytochrome P450 Hepatic transporters
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/59897
专题中国科学院西北高原生物研究所
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GB/T 7714
Yang, Hongxia,Xiao, Yuancan,Li, Cen,et al. Effects on Expression of Hepatic Phase-1 and Phase-2 Metabolism and Transporter Genes by Swertia mussotii Extract, A Hepatoprotective Herb from Tibetan Traditional Medicine[J]. INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGY,2019,21(5).
APA Yang, Hongxia,Xiao, Yuancan,Li, Cen,Gao, Tingting,Wei, Lixin,&Du, Yuzhi.(2019).Effects on Expression of Hepatic Phase-1 and Phase-2 Metabolism and Transporter Genes by Swertia mussotii Extract, A Hepatoprotective Herb from Tibetan Traditional Medicine.INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGY,21(5).
MLA Yang, Hongxia,et al."Effects on Expression of Hepatic Phase-1 and Phase-2 Metabolism and Transporter Genes by Swertia mussotii Extract, A Hepatoprotective Herb from Tibetan Traditional Medicine".INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGY 21.5(2019).
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