pH-Dependent Effects of L-Cysteine on Mercury Dissolution of alpha-HgS and beta-HgS

NWIPB OpenIR

	pH-Dependent Effects of L-Cysteine on Mercury Dissolution of alpha-HgS and beta-HgS
	Zhang, Ming; Bi, Hongtao; Li, Cen; Du, Yuzhi; Wei, Lixin
	2018
发表期刊	BIOLOGICAL TRACE ELEMENT RESEARCH
卷号	185 期号:2
摘要	Mercury sulfide is an insoluble inorganic mercury compound, and it is the main chemical form in traditional oral mercury-containing medicines. Hg2+ has a high affinity for thiols, and small molecule thiols in the gastrointestinal tract may promote mercury dissolution of mercury sulfide by binding to Hg2+. L-cysteine is the only amino acid that possesses a reducing sulfhydryl group (-SH), out of the 20 amino acids. This study investigates the effect of L-cysteine on mercury dissolution of mercury sulfide at pHs ranging from 1.2 to 7.2. The results showed that L-cysteine had different pH-dependent effects on the mercury dissolution of alpha-HgS and beta-HgS. For alpha-HgS, the dissolved mercury concentration increased from 5.47 +/- 0.97 ng/mL to 12.49 +/- 0.54 ng/mL when the pH rose from 1.2 to 4.2, and decreased to 3.37 +/- 0.70 ng/mL at pH 6.0 and then increased to 9.36 +/- 0.79 ng/mL at pH 7.2. For beta-HgS, the dissolved mercury concentration increased from 151.09 +/- 2.25 ng/mL to 2346.71 +/- 62.62 ng/mL when the pH increased from 1.2 to 7.2. In conclusion, L-Cys was distinctly enhanced upon mercury dissolution of alpha-HgS and beta-HgS with increasing pH. These results may contribute to our understanding of the mercury absorption mechanism of traditional oral mercury-containing medicines.
关键词	Mercury sulfide L-cysteine Mercury dissolution pH-dependent effects
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/59956
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhang, Ming,Bi, Hongtao,Li, Cen,et al. pH-Dependent Effects of L-Cysteine on Mercury Dissolution of alpha-HgS and beta-HgS[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2018,185(2).
APA	Zhang, Ming,Bi, Hongtao,Li, Cen,Du, Yuzhi,&Wei, Lixin.(2018).pH-Dependent Effects of L-Cysteine on Mercury Dissolution of alpha-HgS and beta-HgS.BIOLOGICAL TRACE ELEMENT RESEARCH,185(2).
MLA	Zhang, Ming,et al."pH-Dependent Effects of L-Cysteine on Mercury Dissolution of alpha-HgS and beta-HgS".BIOLOGICAL TRACE ELEMENT RESEARCH 185.2(2018).