Effect of Cys, GSH, and pH on Mercury Release from Tibetan Medicine Zuotai, beta-HgS, and alpha-HgS in Artificial Gastrointestinal Juices

NWIPB OpenIR

	Effect of Cys, GSH, and pH on Mercury Release from Tibetan Medicine Zuotai, beta-HgS, and alpha-HgS in Artificial Gastrointestinal Juices
	Zheng, Zhiyuan; Zhang, Ming; Xiao, Yuancan; Wei, Lixin; Li, Cen
	2018
发表期刊	BIOLOGICAL TRACE ELEMENT RESEARCH
卷号	184 期号:2
摘要	Zuotai, also named as "gTso thal", a known Tibetan medicinal mixture containing insoluble cubic crystal mercuric sulfide (beta-HgS), has been used to treat diseases with long history. The mercury release ratio from Zuotai in gastrointestinal environment is one determinant factor for its bioavailability and biological effect. However, the information is still scarce now. Therefore, the study was designed to investigate the effect of sulfhydryl biomolecules [l-cysteine (Cys) and glutathione (GSH)] and pH on mercury dissociation from Zuotai, beta-HgS, and hexagonal crystal mercuric sulfide (alpha-HgS) in artificial gastrointestinal juices or pure water with a 1:100 solid-liquid ratio. And, the digestion and peristalsis of gastrointestinal tract were simulated in vitro. The results showed the following trend for the mercury release ratio of Zuotai, artificial gastric juice > artificial intestinal juice > pure water, whereas the trend for beta-HgS and alpha-HgS was as follows, artificial intestinal fluid > artificial gastric fluid > pure water. The mercury release ratios of Zuotai, beta-HgS, and alpha-HgS significantly increased in artificial intestinal juice containing l-Cys or GSH compared to those without sulfhydryl biomolecules in the juice. However, in contrast to the results observed for beta-HgS and alpha-HgS, the mercury release ratio of Zuotai was reduced remarkably in pure water and artificial gastric juice with Cys or GSH. And, we found that strong acidic or strong alkaline environments promoted the dissociation of mercury from Zuotai, beta-HgS, and alpha-HgS. Taken together, current findings may contribute to other studies regarding clinical safety and bioavailability of the traditional drug Zuotai containing beta-HgS.
关键词	Tibetan medicine Zuotai Mercury release Mercuric sulfide L-Cysteine Glutathione pH
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/59993
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zheng, Zhiyuan,Zhang, Ming,Xiao, Yuancan,et al. Effect of Cys, GSH, and pH on Mercury Release from Tibetan Medicine Zuotai, beta-HgS, and alpha-HgS in Artificial Gastrointestinal Juices[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2018,184(2).
APA	Zheng, Zhiyuan,Zhang, Ming,Xiao, Yuancan,Wei, Lixin,&Li, Cen.(2018).Effect of Cys, GSH, and pH on Mercury Release from Tibetan Medicine Zuotai, beta-HgS, and alpha-HgS in Artificial Gastrointestinal Juices.BIOLOGICAL TRACE ELEMENT RESEARCH,184(2).
MLA	Zheng, Zhiyuan,et al."Effect of Cys, GSH, and pH on Mercury Release from Tibetan Medicine Zuotai, beta-HgS, and alpha-HgS in Artificial Gastrointestinal Juices".BIOLOGICAL TRACE ELEMENT RESEARCH 184.2(2018).