NWIPB OpenIR
Swertia mussotii extracts induce mitochondria-dependent apoptosis in gastric cancer cells
Wang Haixia; Yuan Xiang; Huang Hui-Ming; Zou Shi-Hao; Li Bo; Feng Xi-Qiao; Zhao Hong-Ping
2018
Source PublicationBIOMEDICINE & PHARMACOTHERAPY
Volume104
AbstractSwertia mussotii (Gentianaceae) is a traditional Chinese medicinal plant grown in the Qinghai-Tibet Plateau. Three fractions from S. mussotii extract, named SWF50, SWF70 and SWF100, were screened for in vitro anti-proliferative activity on two gastric cancer cell lines, MGC-803 and BGC-823 cells using MTT assay. Our results demonstrated that SMF70 showed an anti-proliferative effect in MGC-803 cells and SMF100 showed an anti-proliferative effect in BGC-823 cells in vitro. Moreover, both two fractions induced apoptosis via depolymerization of cytoskeletal filaments, increased cytoplasmic levels of ROS and Ca2+ and disrupted mitochondrial transmembrane potential. In addition, flow cytometry analysis indicated that both two fractions could induce cell apoptosis and arrest the cell cycle at S phase. Our results indicate that SMF70 induces apoptosis of MGC-803 cells and SMF100 induces apoptosis of BGC-823 cells via a mitochondrial-dependent pathway. Meanwhile, we also investigated antitumor effect of SMF70 in vivo, and exhibited effective tumor growth inhibition. Our findings demonstrate that S. mussotii extracts could be a potential new alternative therapeutic agent gastric cancer.
KeywordSwertia mussotii Anti-Proliferative Apoptosis Cell cycle Mitochondrial-Dependent
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/59994
Collection中国科学院西北高原生物研究所
Recommended Citation
GB/T 7714
Wang Haixia,Yuan Xiang,Huang Hui-Ming,et al. Swertia mussotii extracts induce mitochondria-dependent apoptosis in gastric cancer cells[J]. BIOMEDICINE & PHARMACOTHERAPY,2018,104.
APA Wang Haixia.,Yuan Xiang.,Huang Hui-Ming.,Zou Shi-Hao.,Li Bo.,...&Zhao Hong-Ping.(2018).Swertia mussotii extracts induce mitochondria-dependent apoptosis in gastric cancer cells.BIOMEDICINE & PHARMACOTHERAPY,104.
MLA Wang Haixia,et al."Swertia mussotii extracts induce mitochondria-dependent apoptosis in gastric cancer cells".BIOMEDICINE & PHARMACOTHERAPY 104(2018).
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