Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models

NWIPB OpenIR

	Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models
	Ma, Ji; Li, Maoru; Kalavagunta, Praveen Kumar; Li, Jiajing; He, Qiangqiang; Zhang, Yifan; Ahmad, Owais; Yin, Hongli; Wang, Tao; Shang, Jing
	2018
发表期刊	BIOMEDICINE & PHARMACOTHERAPY
卷号	104
摘要	Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease with a broad spectrum of liver injury. Oxidant stress is believed to be the pathogenesis of NAFLD as the "second hit". Hydrogen peroxide is widely used as an oxidant reagent to induce the oxidant injury of cells and larval zebrafish. Recently, cichoric acid is being studied extensively for its obesity attenuating, hepatic steatosis reduction and anti-oxidant effects. In this study, to identify whether CRA could protect the H2O2 induced oxidant injury via anti-oxidant impact by using L02 and HepG2 hepatocytes as in vitro and larval zebrafish as in vivo injury models, and evaluated the protective and antioxidant effects of CRA by pretreated it on both in vitro and in vivo models. CRA was found to reduce the production of ROS and MDA, activate the anti-oxidant enzymes SOD and GSH-px, and pathways Keap1-Nrf2 and HO-1. These results demonstrated that CRA might protect the liver injury by its anti-oxidant effect, which could be a potential therapeutic agent of NAFLD.
关键词	Non-alcoholic fatty liver disease Liver injury Oxidative stress Cichoric acid
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/59995
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Ma, Ji,Li, Maoru,Kalavagunta, Praveen Kumar,et al. Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models[J]. BIOMEDICINE & PHARMACOTHERAPY,2018,104.
APA	Ma, Ji.,Li, Maoru.,Kalavagunta, Praveen Kumar.,Li, Jiajing.,He, Qiangqiang.,...&Shang, Jing.(2018).Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models.BIOMEDICINE & PHARMACOTHERAPY,104.
MLA	Ma, Ji,et al."Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models".BIOMEDICINE & PHARMACOTHERAPY 104(2018).