Dracocephalum heterophyllum(DH) Exhibits Potent Anti-Proliferative Effects on Autoreactive CD4(+)T Cells and Ameliorates the Development of Experimental Autoimmune Uveitis

NWIPB OpenIR

	Dracocephalum heterophyllum(DH) Exhibits Potent Anti-Proliferative Effects on Autoreactive CD4(+)T Cells and Ameliorates the Development of Experimental Autoimmune Uveitis
	Bian, Jiang; Wang, Ke; Wang, Qilan; Wang, Pu; Wang, Ting; Shi, Weiyun; Ruan, Qingguo
	2020
发表期刊	FRONTIERS IN IMMUNOLOGY
卷号	11
摘要	Experimental autoimmune uveitis (EAU) is a CD4(+)T cell-mediated organ-specific autoimmune disease and has been considered as a model of human autoimmune uveitis.Dracocephalum heterophyllum(DH) is a Chinese herbal medicine used in treating hepatitis. DH suppressed the production of inflammatory cytokines through the recruitment of myeloid-derived suppressor cells (MDSCs) to the liver. However, it remains elusive whether DH can directly regulate CD4(+)T cell biology and hence ameliorates the development of CD4(+)T cell-mediated autoimmune disease. In the current study, we found that DH extract significantly suppressed the production of pro-inflammatory cytokines by CD4(+)T cells. Further study showed that DH didn't affect the activation, differentiation, and apoptosis of CD4(+)T cells. Instead, it significantly suppressed the proliferation of conventional CD4(+)T cells bothin vitroandin vivo. Mechanistic study showed that DH-treated CD4(+)T cells were partially arrested at the G2/M phase of the cell cycle because of the enhanced inhibitory phosphorylation of Cdc2 (Tyr15). In addition, we demonstrated that treatment with DH significantly ameliorated EAU in mice through suppressing the proliferation of autoreactive antigen specific CD4(+)T cells. Taken together, the current study indicates that DH-mediated suppression of CD4(+)T cell proliferation may provide a promising therapeutic strategy for treating CD4(+)T cell-mediated diseases.
关键词	autoimmunity proliferation herbal medicine T cell experimental autoimmune uveitis
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60230
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Bian, Jiang,Wang, Ke,Wang, Qilan,et al. Dracocephalum heterophyllum(DH) Exhibits Potent Anti-Proliferative Effects on Autoreactive CD4(+)T Cells and Ameliorates the Development of Experimental Autoimmune Uveitis[J]. FRONTIERS IN IMMUNOLOGY,2020,11.
APA	Bian, Jiang.,Wang, Ke.,Wang, Qilan.,Wang, Pu.,Wang, Ting.,...&Ruan, Qingguo.(2020).Dracocephalum heterophyllum(DH) Exhibits Potent Anti-Proliferative Effects on Autoreactive CD4(+)T Cells and Ameliorates the Development of Experimental Autoimmune Uveitis.FRONTIERS IN IMMUNOLOGY,11.
MLA	Bian, Jiang,et al."Dracocephalum heterophyllum(DH) Exhibits Potent Anti-Proliferative Effects on Autoreactive CD4(+)T Cells and Ameliorates the Development of Experimental Autoimmune Uveitis".FRONTIERS IN IMMUNOLOGY 11(2020).