Arenaria kansuensis attenuates pulmonary fibrosis in mice via the activation of Nrf2 pathway and the inhibition ofNF-kB/TGF-beta1/Smad2/3 pathway

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	Arenaria kansuensis attenuates pulmonary fibrosis in mice via the activation of Nrf2 pathway and the inhibition ofNF-kB/TGF-beta1/Smad2/3 pathway
	Cui, Yulei; Xin, Huawei; Tao, Yanduo; Mei, Lijuan; Wang, Zhen
	2020
发表期刊	PHYTOTHERAPY RESEARCH
摘要	Pulmonary fibrosis is a key feature of COVID-19, Chinese herbal medicineArenaria kansuensishas been used for curing pulmonary disease and antivirus for a long time and it has the potential against COVID-19. In this work, protective effect ofA. kansuensisethanol extract (AE) on pulmonary fibrosis was evaluated through paraquat (PQ)-induced pulmonary fibrosis animal model. Results showed that AE could significantly improve the survival rate, increase the body weight and reduce the lung index of mice at the raw drug doses of 700 and 350 mg/kg. Histopathological observation results showed that the destruction degree of lung tissue structure in mice was significantly improved with the increase of AE dosage. Collagen deposition in lung interstitium was significantly reduced. The marker protein alpha-SMA involved in PF were significantly inhibited through repressing TGF-beta1/Smads pathway. The degree of inflammatory infiltration was significantly reduced and inflammatory cytokines were significantly inhibited in mice through inhibiting the NF-kB-p65. Besides, oxidant stress level including upregulated ROS and down-regulated SOD and GSH was efficiently improved by AE through upregulation of Nrf2 and downregulation of NOX4. In summary, this study firstly showed that the protective effect of AE on pulmonary fibrosis was partly due to activation of Nrf2 pathway and the inhibition of NF-kB/TGF-beta1/Smad2/3 pathway.
关键词	Arenaria kansuensis COVID-19 inflammation oxidative stress pulmonary fibrosis
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60241
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Cui, Yulei,Xin, Huawei,Tao, Yanduo,et al. Arenaria kansuensis attenuates pulmonary fibrosis in mice via the activation of Nrf2 pathway and the inhibition ofNF-kB/TGF-beta1/Smad2/3 pathway[J]. PHYTOTHERAPY RESEARCH,2020.
APA	Cui, Yulei,Xin, Huawei,Tao, Yanduo,Mei, Lijuan,&Wang, Zhen.(2020).Arenaria kansuensis attenuates pulmonary fibrosis in mice via the activation of Nrf2 pathway and the inhibition ofNF-kB/TGF-beta1/Smad2/3 pathway.PHYTOTHERAPY RESEARCH.
MLA	Cui, Yulei,et al."Arenaria kansuensis attenuates pulmonary fibrosis in mice via the activation of Nrf2 pathway and the inhibition ofNF-kB/TGF-beta1/Smad2/3 pathway".PHYTOTHERAPY RESEARCH (2020).