Ionic silver-infused peroxidase-like metal-organic frameworks as versatile "antibiotic" for enhanced bacterial elimination

NWIPB OpenIR

	Ionic silver-infused peroxidase-like metal-organic frameworks as versatile "antibiotic" for enhanced bacterial elimination
	Zhang, Wentao; Ren, Xinyi; Shi, Shuo; Li, Min; Liu, Lizhi; Han, Ximei; Zhu, Wenxin; Yue, Tianli; Sun, Jing; Wang, Jianlong
	2020
发表期刊	NANOSCALE
卷号	12 期号:30
摘要	The fabrication of multiple antibacterial modalities for combating bacterial pathogens and treating infected wounds is of vital importance. Accordingly, nanozymes have emerged as a new generation of "antibiotics" with broad-spectrum antibacterial potency and high stability; however, the further application of nanozymes in clinical medicine is still limited by their single-modal antibacterial process, which cannot eradicate bacteria totally. Herein, we infused the NH2-MIL-88B(Fe) peroxidase-like nanomaterial with a small amount of Ag(i) to construct NH2-MIL-88B(Fe)-Ag, a potent and benign "antibiotic" with the ability to eliminate bacteria completely. This versatile system could efficiently convert H(2)O(2)into the more toxic & x2d9;OH and release Ag(i) simultaneously, making pathogenic bacteria more vulnerable to be eliminated, which decreased the requirement for the toxic H(2)O(2)and high concentration of Ag(i). More importantly, thein vivoresults indicated that the synergistic germicidal system could be used for wound disinfection successfully with excellent antibacterial efficacy and negligible biotoxicity. This strategy paves the way for the development of integrated antibacterial agents with enhanced antibacterial function and alternative antibiotics.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60275
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhang, Wentao,Ren, Xinyi,Shi, Shuo,et al. Ionic silver-infused peroxidase-like metal-organic frameworks as versatile "antibiotic" for enhanced bacterial elimination[J]. NANOSCALE,2020,12(30).
APA	Zhang, Wentao.,Ren, Xinyi.,Shi, Shuo.,Li, Min.,Liu, Lizhi.,...&Wang, Jianlong.(2020).Ionic silver-infused peroxidase-like metal-organic frameworks as versatile "antibiotic" for enhanced bacterial elimination.NANOSCALE,12(30).
MLA	Zhang, Wentao,et al."Ionic silver-infused peroxidase-like metal-organic frameworks as versatile "antibiotic" for enhanced bacterial elimination".NANOSCALE 12.30(2020).