Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease

NWIPB OpenIR

	Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease
	Liu, Fengyun; Fan, Chao; Zhang, Liangzhi; Li, Yuan; Hou, Haiwen; Ma, Yan; Fan, Jinhua; Tan, Yueqin; Wu, Tianyi; Jia, Shangang; Zhang, Yanming
	2020
发表期刊	FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷号	10
摘要	Coronary heart disease (CHD) is closely related to gut microbiota, which may be significantly affected by ethnicity and the environment. Knowledge regarding the gut microbiome of Tibetan CHD patients living in the Qinghai-Tibet Plateau is very limited. In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD). We analyzed the alterations of the gut microbiome in CHD patients and investigated the relationship between these alterations and the pathological indicators. We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group. The gut microbiota of the NCHD group had a significantly higher Shannon index than that of the HT group. Adonis analysis showed that both microbial compositions and functions of the three groups were significantly separated. TheDialistergenus was significantly lower andBlautia, Desulfovibrio, andSuccinivibriowere significantly higher in abundance in CHD patients compared with the HT group, and the changes were significantly correlated with physiological indexes, such as increased lipopolysaccharides. Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group. Additionally, occupation and a family history of CHD were shown to be risk factors and affected the gut microbiota in Tibetans. Our study will provide insights into the understanding of CHD, leading to better diagnosis and treatment of Tibetan patients.
关键词	gut microbiome 16S rDNA metagenome coronary heart disease (CHD) Tibetan lipopolysaccharide (LPS)
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60291
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Liu, Fengyun,Fan, Chao,Zhang, Liangzhi,et al. Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease[J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2020,10.
APA	Liu, Fengyun.,Fan, Chao.,Zhang, Liangzhi.,Li, Yuan.,Hou, Haiwen.,...&Zhang, Yanming.(2020).Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,10.
MLA	Liu, Fengyun,et al."Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 10(2020).