Leucine-coated cobalt ferrite nanoparticles: Synthesis, characterization and potential biomedical applications for drug delivery

NWIPB OpenIR

	Leucine-coated cobalt ferrite nanoparticles: Synthesis, characterization and potential biomedical applications for drug delivery
	Zhang, Hui; Wang, Jianchao; Zeng, Yingzhe; Wang, Guangshuo; Han, Shuai; Yang, Zhitang; Li, Baowei; Wang, Xiaomin; Gao, Jie; Zheng, Liyun; Liu, Xiaoyan; Huo, Zhongchao; Yu, Ruitao
	2020
发表期刊	PHYSICS LETTERS A
卷号	384 期号:24
摘要	This work was primarily focused on the synthesis, characterization and biomedical applications of cobalt ferrite (CoFe2O4) nanoparticles, which were synthesized by a facile solvothermal method using an amino acid of Leucine (Leu) as the surface coating agents. The morphology, structure and properties of the as-synthesized uncoated and Leu-coated CoFe2O4 nanoparticles were characterized in detail by means of XRD, SEM, TEM, DLS, FTIR, XPS, TGA and SQUID. More importantly, it was found that the Leu-coated CoFe2O4 nanoparticles can be used as the efficient drug delivery with a drug loading capacity of 0.32 mg/mg for doxorubicin hydrochloride (DOX), and the loaded DOX demonstrated a sustained and progressive release manner. The in vitro cytotoxicity studies towards the HeLa cells were carried out, and the results indicated that the Leu-coated CoFe2O4 nanoparticles exhibited a relatively high cell viability compared with that of bare CoFe2O4 nanoparticles and the DOX loaded Leu-coated CoFe2O4 nanoparticles presented an obvious cytotoxic effect on HeLa cells. (C) 2020 Elsevier B.V. All rights reserved.
关键词	CoFe2O4 nanoparticles Leucine Controlled synthesis Biocompatibility Drug delivery
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60348
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhang, Hui,Wang, Jianchao,Zeng, Yingzhe,et al. Leucine-coated cobalt ferrite nanoparticles: Synthesis, characterization and potential biomedical applications for drug delivery[J]. PHYSICS LETTERS A,2020,384(24).
APA	Zhang, Hui.,Wang, Jianchao.,Zeng, Yingzhe.,Wang, Guangshuo.,Han, Shuai.,...&Yu, Ruitao.(2020).Leucine-coated cobalt ferrite nanoparticles: Synthesis, characterization and potential biomedical applications for drug delivery.PHYSICS LETTERS A,384(24).
MLA	Zhang, Hui,et al."Leucine-coated cobalt ferrite nanoparticles: Synthesis, characterization and potential biomedical applications for drug delivery".PHYSICS LETTERS A 384.24(2020).