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In Situ Cascade Derivation toward a Hierarchical Layered Double Hydroxide Magnetic Absorbent for High-Performance Protein Separation
Shi, Shuo; Zhang, Wentao; Wu, Haofen; Li, Yuchen; Ren, Xinyi; Li, Min; Liu, Jie; Sun, Jing; Yue, Tianli; Wang, Jianlong
2020
发表期刊ACS SUSTAINABLE CHEMISTRY & ENGINEERING
卷号8期号:12
摘要Selective enrichment and purification of histidine (His)-rich protein from complex mixtures is vital to satisfy the requirements of proteomic and diagnostic applications, but it still remain a challenge. Herein, a high-performance layered double hydroxide (LDH)-based adsorbent is designed and prepared, via a metal-organic framework (MOF)-mediated in situ cascade derivation strategy, for enhanced His-rich protein separation. Importantly, the pseudomorphic conversion of Fe3O4 nanoparticle-derived magnetic MIL-100(Fe) MOF, with unique structural features, enables the finally derived LDH with plenty of Ni2+ ions exposed for His-rich protein binding. As such, the as-prepared Fe3O4@NiFe LDH exhibits favorable selectivity for His-rich protein adsorption with bovine hemoglobin (BHb) as a model and with a relatively high binding capacity of 3287.67 mg g(-1) in a rapid equilibrium time of 20 min, which is superior to those reported magnetic adsorbents. Also, the high performance of Fe3O4@NiFe LDH can be facilely regenerated and applied to separate BHb from a bovine blood sample, highlighting its good practicality. Therefore, this MOF-mediated cascade derivation strategy is a promising way to design advanced layered double hydroxide magnetic adsorbents for high-performance bioseparation.
关键词Histidine-rich protein High-performance Separation MOF-mediated cascade derivation Layered double hydroxide
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/60380
专题中国科学院西北高原生物研究所
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GB/T 7714
Shi, Shuo,Zhang, Wentao,Wu, Haofen,et al. In Situ Cascade Derivation toward a Hierarchical Layered Double Hydroxide Magnetic Absorbent for High-Performance Protein Separation[J]. ACS SUSTAINABLE CHEMISTRY & ENGINEERING,2020,8(12).
APA Shi, Shuo.,Zhang, Wentao.,Wu, Haofen.,Li, Yuchen.,Ren, Xinyi.,...&Wang, Jianlong.(2020).In Situ Cascade Derivation toward a Hierarchical Layered Double Hydroxide Magnetic Absorbent for High-Performance Protein Separation.ACS SUSTAINABLE CHEMISTRY & ENGINEERING,8(12).
MLA Shi, Shuo,et al."In Situ Cascade Derivation toward a Hierarchical Layered Double Hydroxide Magnetic Absorbent for High-Performance Protein Separation".ACS SUSTAINABLE CHEMISTRY & ENGINEERING 8.12(2020).
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