Mesoporous superparamagnetic cobalt ferrite nanoclusters: Synthesis, characterization and application in drug delivery

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	Mesoporous superparamagnetic cobalt ferrite nanoclusters: Synthesis, characterization and application in drug delivery
	Shi, Zhimin; Zeng, Yingzhe; Chen, Xin; Zhou, Fei; Zheng, Liyun; Wang, Guangshuo; Gao, Jie; Ma, Yingying; Zheng, Lianhong; Fu, Bin; Yu, Ruitao
	2020
发表期刊	JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
卷号	498
摘要	In this contribution, an amino acid of L-Arginine coated cobalt ferrite (CoFe2O4) nanoclusters with mesoporous structure were synthesized via a facile solvothermal strategy. The morphology, structure and properties of bare CoFe2O4 and L-Arg-coated CoFe2O4 nanoclusters were characterized in detail by SEM, TEM, XRD, XPS, TGA, BET and SQUID. It was found that these products exhibited a well-defined clusters-like morphology and a uniform size distribution with an average diameter of 103.6 nm. The as-prepared superparamagnetic CoFe2O4 nanoclusters with mesoporous structure and negligible cytotoxicity could be utilized as an effective drug delivery for doxorubicin hydrochloride (DOX). The drug loading capacity and the release behavior in vitro of DOX from L-Arg-coated CoFe2O4 nanoclusters at different pH values (4.0 and 7.4) were investigated. The results showed that the developed drug delivery system exhibited a high drug loading capacity and a pH-sensitive drug release behavior.
关键词	Cobalt ferrite L-Arginine Nanoclusters Mesoporous Superparamagnetic Drug delivery
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60386
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Shi, Zhimin,Zeng, Yingzhe,Chen, Xin,et al. Mesoporous superparamagnetic cobalt ferrite nanoclusters: Synthesis, characterization and application in drug delivery[J]. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS,2020,498.
APA	Shi, Zhimin.,Zeng, Yingzhe.,Chen, Xin.,Zhou, Fei.,Zheng, Liyun.,...&Yu, Ruitao.(2020).Mesoporous superparamagnetic cobalt ferrite nanoclusters: Synthesis, characterization and application in drug delivery.JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS,498.
MLA	Shi, Zhimin,et al."Mesoporous superparamagnetic cobalt ferrite nanoclusters: Synthesis, characterization and application in drug delivery".JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 498(2020).