Immunostimulating effect of polysaccharides isolated from Ma-Nuo-Xi decoction in cyclophosphamide-immunosuppressed mice

NWIPB OpenIR

	Immunostimulating effect of polysaccharides isolated from Ma-Nuo-Xi decoction in cyclophosphamide-immunosuppressed mice
	Jie, Duo; Gao, Tingting; Shan, Zhongshu; Song, Jiayin; Zhang, Ming; Kurskaya, Olga; Sharshov, Kirill; We, Lixin; Bi, Hongtao
	2020
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷号	146
摘要	Ma-Nuo-Xi Decoction (MNXD) is well-known in Tibetan medicine to be in line with the theory of treatment determination based on syndrome differentiation. However, the components responsible for its immunomodulating effect are unknown. In this study, three polysaccharide components-MNXD-P, MNXD-BD-P, and MNXD-AD-P-were isolated from MNXD and its basic and auxiliary prescription decoctions, of which MNXD-BD-P is composed of beta-(1,4)-d-glucan and RG-I pectin, MNXD-AD-P contains mainly alpha-(1,4)-D-glucan and some amount of arabinogalactan and/or arabinorhamnogalactan, and MNXD-P contains components of both MNXD-BD-P and MNXD-AD-P. And treatment with these polysaccharides could significantly improve the host's specific and non-specific immunity, including cellular and humoral immunities, as well as promote recovery from myelosuppression in cyclophosphamide (CTX)-immunosuppressed mice. To our knowledge, this is the first report on chemical and immunoactivity study on polysaccharides from traditional Tibetan medicine compounds, which may provide a new idea for development of carbohydrate drugs from them. (C) 2019 Published by Elsevier B.V.
关键词	Ma-Nuo-Xi decoction Polysaccharide lmmunostimulating effect Cyclophosphamide-induced immunosuppression Tibetan medicine
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60393
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Jie, Duo,Gao, Tingting,Shan, Zhongshu,et al. Immunostimulating effect of polysaccharides isolated from Ma-Nuo-Xi decoction in cyclophosphamide-immunosuppressed mice[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,146.
APA	Jie, Duo.,Gao, Tingting.,Shan, Zhongshu.,Song, Jiayin.,Zhang, Ming.,...&Bi, Hongtao.(2020).Immunostimulating effect of polysaccharides isolated from Ma-Nuo-Xi decoction in cyclophosphamide-immunosuppressed mice.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,146.
MLA	Jie, Duo,et al."Immunostimulating effect of polysaccharides isolated from Ma-Nuo-Xi decoction in cyclophosphamide-immunosuppressed mice".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 146(2020).